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Invitrogen
MYO6 Polyclonal Antibody
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MYO6 Antibody (PA5-110004) in WB
Western blot analysis of MYO6 in extracts of various cell lines. Samples were incubated with MYO6 Polyclonal antibody (Product # PA5-110004) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-110004
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1016-1285 of human MYO6 (NP_004990.3).
Conjugate
Form
Liquid
Concentration
2.24 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855415
Product Specific Information
Immunogen sequence: IAQSEAELIS DEAQADLALR RNDGTRPKMT PEQMAKEMSE FLSRGPAVLA TKAAAGTKKY DLSKWKYAEL RDTINTSCDI ELLAACREEF HRRLKVYHAW KSKNKKRNTE TEQRAPKSVT DYDFAPFLNN SPQQNPAAQI PARQREIEMN RQQRFFRIPF IRPADQYKDP QSKKKGWWYA HFDGPWIARQ MELHPDKPPI LLVAGKDDME MCELNLEETG LTRKRGAEIL PRQFEEIWER CGGIQYLQNA IESRQARPTY ATAMLQSLLK
Target Information
This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: myosin VI; myosin-VI; Protein twist; Snell's waltzer; tailchaser; Unconventional myosin-6; Unconventional myosin-VI
Gene Aliases: BC029719; DFNA22; DFNB37; KIAA0389; MYO6; RGD1560646; Sv; Tlc
UniProt ID: (Human) Q9UM54, (Mouse) Q64331
Entrez Gene ID: (Human) 4646, (Mouse) 17920, (Rat) 315840
protein targeting
transport
endocytosis
chemical synaptic transmission
synapse assembly
sensory perception of sound
locomotory behavior
glutamate secretion
protein transport
dendrite development
DNA damage response, signal transduction by p53 class mediator
inner ear morphogenesis
auditory receptor cell differentiation
response to drug
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
inner ear development
regulation of secretion
cellular response to electrical stimulus
intracellular protein transport
actin filament-based movement
cell-cell adhesion
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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