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Immunogen sequence: TDGERSAKKP AVQKKKPGDA SSLPDAGLSP GSQVDSKSTF KRLFLHKTKD KKYSLEGAEE LENAVSGHVV LEATTM
Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 62%.
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: celiac disease 4; myosin; myosin-IXb; unconventional myosin IXb; Unconventional myosin-9b; Unconventional myosin-IXb
Gene Aliases: CELIAC4; MYO9B; MYR5
UniProt ID: (Human) Q13459
Entrez Gene ID: (Human) 4650
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