Invitrogen

MYOCD Monoclonal Antibody (355521)

1 Published Figure
1 Reference
View all (6) MYOCD antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-24103

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
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Product Specifications

Species Reactivity

Human, Mouse

Published species

Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

355521

Immunogen

E. coli-derived recombinant human Myocardin Met97-Leu290
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606771

Product Specific Information

Reconstitute at 0.5 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Basic SAP coiled-coil transcription activator 2; Myocardin; SRF co-factor protein (cardiac and smooth muscle); SRF cofactor protein

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Gene Aliases: Bsac2; BSAC2A; MYCD; MYOCD; Srfcp

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UniProt ID: (Human) Q8IZQ8, (Mouse) Q8VIM5

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Entrez Gene ID: (Human) 93649, (Mouse) 214384

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Function(s)
core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding transcription factor binding histone acetyltransferase binding histone deacetylase binding R-SMAD binding transcription coactivator activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of cell growth by extracellular stimulus vasculogenesis cardiac ventricle development positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of cardiac muscle cell apoptotic process negative regulation of myotube differentiation positive regulation of transforming growth factor beta receptor signaling pathway regulation of histone acetylation hepatic stellate cell activation muscle cell differentiation positive regulation of DNA binding cellular component maintenance regulation of myoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction lung alveolus development digestive tract development positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation regulation of smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation uterus development urinary bladder development cell growth involved in cardiac muscle cell development ductus arteriosus closure negative regulation of beta-amyloid clearance positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation positive regulation of cardiac vascular smooth muscle cell differentiation positive regulation of cardiac muscle cell differentiation negative regulation of skeletal muscle cell differentiation response to hypoxia cardiocyte differentiation vascular smooth muscle cell differentiation cellular response to growth factor stimulus cellular response to hypoxia regulation of phenotypic switching
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