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The MW of this protein is 32 kDa, and 13160-1-AP specifically recognizes the 32 kDa protein.
Immunogen sequence: MPLSGTPAP NKKRKSSKLI MELTGGGQES SGLNLGKKIS VPRDVMLEEL SLLTNRGSKM FKLRQMRVEK FIYENHPDVF SDSSMDHFQK FLPTVGGQLG TAGQGFSYSK SNGRGGSQAG GSGSAGQYGS DQQHHLGSGS GAGGTGGPAG QAGRGGAAGT AGVGETGSGD QAGGEGKHIT VFKTYISPWE RAMGVDPQQK MELGIDLLAY GAKAELPKYK SFNRTAMPYG GYEKASKRMT FQMPKFDLGP LLSEPLVLYN QNLSNRPSFN RTPIPWLSSG EPVDYNVDIG IPLDGETEEL (1-299 aa encoded by BC025753)
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: calcineurin-2; Calsarcin-2; Filamin-, actinin- and telethonin-binding protein; MYOZ1; Myozenin-1; Protein FATZ; skeletal muscle-specific protein
Gene Aliases: 2310001N11Rik; AV090278; CS-2; FATZ; MYOZ; MYOZ1; RGD1561064
UniProt ID: (Human) Q9NP98, (Mouse) Q9JK37
Entrez Gene ID: (Human) 58529, (Mouse) 59011, (Rat) 498440
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