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Invitrogen
MYSM1 Polyclonal Antibody
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FIGURE: 1 / 1
MYSM1 Antibody (PA5-91929) in WB
Western blot analysis of MYSM1 in extracts of various cell lines. Samples were incubated with MYSM1 Polyclonal antibody (Product # PA5-91929) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-91929
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 720-821 of human MYSM1 (NP_0010789561)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806331
Product Specific Information
Positive Samples: U-87MG, A-431, HepG2, HeLa, Jurkat, Mouse brain, Rat brain; Cellular Location: Nucleus
Immunogen sequence: SYRLPYKFEV QQMLEEPQWG LVFEKTRWII EKYRLSHSSV PMDKIFRRDS DLTCLQKLLE CMRKTLSKVT NCFMAEEFLT EIENLFLSNY KSNQENGVTE EN
Target Information
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2A-DUB; Deubiquitinase MYSM1; histone H2A deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1; Myb-like, SWIRM and MPN domains 1; RP4-592A1.1
Gene Aliases: 2A-DUB; 2ADUB; C130067A03Rik; C530050H10Rik; KIAA1915; MYSM1; RGD1311787
UniProt ID: (Human) Q5VVJ2, (Mouse) Q69Z66
Entrez Gene ID: (Human) 114803, (Rat) 298247, (Mouse) 320713
chromatin remodeling
proteolysis
biological_process
monoubiquitinated histone H2A deubiquitination
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
regulation of cell migration
regulation of hair follicle development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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