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Invitrogen
MYST1 Polyclonal Antibody
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MYST1 Antibody (PA5-96098) in WB
Western blot analysis of MYST1 in extracts of various cell lines. Samples were incubated with MYST1 Polyclonal antibody (Product # PA5-96098) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96098
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KAT8/MYST1/MOF (NP_8920032)
Conjugate
Form
Liquid
Concentration
1.76 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2807900
Product Specific Information
Immunogen sequence: MAAQGAAAAV AAGTSGVAGE GEPGPGENAA AEGTAPSPGR VSPPTPARGE PEVTVEIGET YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL DEWVDKNRLA LTKTVKDAVQ KNSEKYLSEL AEQPERKITR NQKRKHDEIN HVQKTYAEMD PTTAALEKEH EAITKVKYVD KIHIGNYEID AWYFSPFPED; Positive Samples: OVCAR3, NIH/3T3; Cellular Location: Chromosome, Nucleus
Target Information
The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3), yeast YBF2 and SAS2, and TIP60 (HTATIP). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h FLJ14040; Histone acetyltransferase KAT8; histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; Lysine acetyltransferase 8; Males-absent on the first protein homolog; mMof; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST protein 1; MYST-1; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1; Protein acetyltransferase KAT8; Protein propionyltransferase KAT8
Gene Aliases: 2010203C02Rik; 5830450F21Rik; D7Ertd629e; hMOF; KAT8; MOF; MYST1; PP7073; ZC2HC8
UniProt ID: (Human) Q9H7Z6, (Mouse) Q9D1P2, (Rat) Q5XI06
Entrez Gene ID: (Human) 84148, (Mouse) 67773, (Rat) 310194
histone acetyltransferase activity
protein binding
transcription factor binding
acetyltransferase activity
enzyme binding
methylated histone binding
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
metal ion binding
histone acetyltransferase activity (H4-K16 specific)
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
molecular_function
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of autophagy
chromatin modification
histone acetylation
myeloid cell differentiation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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