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NeoBiotechnologies
Macrophage L1 Protein Monoclonal Antibody (SPM281)
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Product Details
6279-MSM1X-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Cat,
Guinea pig,
Goat,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
SPM281
Immunogen
Affinity Purified monocyte membrane preparation
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI323541; B8Ag; BEE11; BEE22; calgranulin A; calgranulin B; Calgranulin-A; Calgranulin-B; calprotectin; Calprotectin L1H subunit; Calprotectin L1L subunit; CFAG; Chemotactic cytokine CP-10; chemotactic S100 protein; Cystic fibrosis antigen; intracellular calcium-binding protein (MRP14); Leukocyte L1 complex heavy chain; Leukocyte L1 complex light chain; macrophage migration inhibitory factor-related protein-8; Migration inhibitory factor-related protein 14; Migration inhibitory factor-related protein 8; MRP-14; MRP-8; Myeloid-related protein 14; Neutrophil cytosolic 23 kDa protein; Neutrophil cytosolic 7 kDa protein; p14; p23; P7; p8; Pro-inflammatory S100 cytokine; Protein S100-A8; Protein S100-A9; RNA-binding region containing protein 2-like; S100 calcium binding protein A8 (calgranulin A); S100 calcium binding protein A9 (calgranulin B); S100 calcium-binding protein A8; S100 calcium-binding protein A8 (calgranulin A); S100 calcium-binding protein A9; S100 calcium-binding protein A9 (calgranulin B); S100A8/S100A9; Urinary stone protein band A
Gene Aliases: 60B8AG; AI323541; AW546964; B8Ag; BEE22; BOS_2815; BOS_2834; CAGA; CAGB; CFAG; CGLA; CGLB; CP-10; GAGB; L1AG; LIAG; MA387; MAC387; MIF; MRP-14; MRP14; MRP8; NIF; P14; P8; S100A8; S100A9
leukocyte migration involved in inflammatory response
autophagy
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
neutrophil chemotaxis
innate immune response
positive regulation of inflammatory response
neutrophil aggregation
positive regulation of intrinsic apoptotic signaling pathway
acute inflammatory response
chronic inflammatory response
positive regulation of peptide secretion
inflammatory response
response to zinc ion
response to lipopolysaccharide
wound healing
response to ethanol
immune system process
regulation of translation
chemotaxis
peptidyl-cysteine S-nitrosylation
leukocyte chemotaxis
actin cytoskeleton reorganization
peptidyl-cysteine S-trans-nitrosylation
regulation of integrin biosynthetic process
regulation of inflammatory response
cytokine production
signal transduction
cell-cell signaling
astrocyte development
positive regulation of blood coagulation
positive regulation of cell growth
sequestering of zinc ion
chemokine production
defense response to bacterium
defense response to fungus
positive regulation of NF-kappaB transcription factor activity
regulation of cytoskeleton organization
cellular oxidant detoxification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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