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Bethyl Laboratories
MafA Polyclonal Antibody
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Product Details
IHC-00352
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 300 and the C-terminus (residue 359) of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog A.
Conjugate
Form
Liquid
Concentration
50 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its ocogenic activity. Serves as an ocogene or tumor supressor depending on the cell context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mafa homolog; Pancreatic beta-cell-specific transcriptional activator; Transcription factor MafA; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
Gene Aliases: Mafa; RIPE3b1
UniProt ID: (Mouse) Q8CF90
Entrez Gene ID: (Mouse) 378435
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nitric oxide mediated signal transduction
response to glucose
insulin secretion
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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