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Invitrogen
Matuzumab Recombinant Human Monoclonal Antibody (Matuzumab)
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Matuzumab Antibody (MA5-47997) in ELISA
ELISA analysis of Matuzumab recombinant monoclonal antibody (Product # MA5-47997) was performed by coating plate with Matuzumab-Fc at a concentration of 5 µg/mL. A 3-fold serial dilution from 100 to 0.1 ng/mL of the antibody was performed. For detection, a 1:4,000 dilution of HRP labelled anti-human kappa light chain antibody was used.
Product Details
MA5-47997
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Matuzumab
Immunogen
Domain III of the extracellular domain of human EGRF.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074440
Product Specific Information
Specificity: This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding. This antibody can only recognize the active form of EGFR. The antibody binds to both glyco- and aglyco receptor forms.
Target Information
Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR, frequently associated with the growth of blood vessels in malignancy, facilitating tumor growth and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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