Invitrogen

Melan-A Monoclonal Antibody (A103)

Melan-A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Melan-A Antibody (MA5-14168) in IHC (P)

Immunohistochemical analysis of Melan-A was performed using formalin-fixed paraffin-embedded human skin (malignant melanoma) tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius... View More

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Product Details

MA5-14168

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50-1:750

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

A103

Immunogen

Recombinant MART-1 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_10985481

Product Specific Information

MA5-14168 targets MART-1 in IHC (P) and WB applications and shows reactivity with Human samples.

The MA5-14168 immunogen is recombinant MART-1 protein.

Target Information

MART1 is involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cellular architecture of human brain metastases.

Cell

Gonzalez H,Mei W,Robles I,Hagerling C,Allen BM,Hauge Okholm TL,Nanjaraj A,Verbeek T,Kalavacherla S,van Gogh M,Georgiou S,Daras M,Phillips JJ,Spitzer MH,Roose JP,Werb Z

MA5-14168 was used in Immunohistochemistry to present an integrative analysis of >100,000 malignant and non-malignant cells from 15 human parenchymal BrMs, generated by single-cell transcriptomics, mass cytometry, and complemented with mouse model- and in silico approaches.

Thu Feb 17 00:00:00 UTC 2022

Xp11.2 translocation renal cell carcinoma with NONO-TFE3 gene fusion: morphology, prognosis, and potential pitfall in detecting TFE3 gene rearrangement.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Xia QY,Wang Z,Chen N,Gan HL,Teng XD,Shi SS,Wang X,Wei X,Ye SB,Li R,Ma HH,Lu ZF,Zhou XJ,Rao Q

MA514168 was used in immunohistochemistry - paraffin section to characterize eight cases of renal cell carcinoma cases with NONO-TFE3

Wed Mar 01 00:00:00 UTC 2017

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

Molecular oncology

Woan KV,Lienlaf M,Perez-Villaroel P,Lee C,Cheng F,Knox T,Woods DM,Barrios K,Powers J,Sahakian E,Wang HW,Canales J,Marante D,Smalley KSM,Bergman J,Seto E,Kozikowski A,Pinilla-Ibarz J,Sarnaik A,Celis E,Weber J,Sotomayor EM,Villagra A

MA5-14168 was used in western blot to determine which HDAC to target to specifically inhibit metastatic melanoma

Sat Aug 01 00:00:00 UTC 2015

Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature.

Diagnostic pathology

Ertoy Baydar D,Kosemehmetoglu K,Aydin O,Bridge JA,Buyukeren B,Aki FT

MA5-14168 was used in immunohistochemistry to present two cases of primary sclerosing epithelioid fibrosarcoma of the kidney

Fri Oct 09 00:00:00 UTC 2015

Loss of BRM expression is a frequently observed event in poorly differentiated clear cell renal cell carcinoma.

Histopathology

Xia QY,Rao Q,Cheng L,Shen Q,Shi SS,Li L,Liu B,Zhang J,Wang YF,Shi QL,Wang JD,Ma HH,Lu ZF,Yu B,Zhang RS,Zhou XJ

MA5-14168 was used in immunohistochemistry to study the incidence of BRM expression loss in patients with poorly differentiated clear cell renal cell carcinoma

Thu May 01 00:00:00 UTC 2014

Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas): a clinicopathological study emphasizing extrarenal PEComas.

Histopathology

Rao Q,Cheng L,Xia QY,Liu B,Li L,Shi QL,Shi SS,Yu B,Zhang RS,Ma HH,Lu ZF,Tu P,Zhou XJ

MA5-14168 was used in immunohistochemistry to study the expression and diagnostic value of cathepsin K expression in a wide range of extra-renal perivascular epithelioid cell neoplasms

Fri Mar 01 00:00:00 UTC 2013

Renal cell carcinomas with t(6;11)(p21;q12) presenting with tubulocystic renal cell carcinoma-like features.

International journal of clinical and experimental pathology

Rao Q,Zhang XM,Tu P,Xia QY,Shen Q,Zhou XJ,Shi QL

MA5-14168 was used in immunohistochemistry to report on a case of renal cell carcinoma with t(6;11)(p21;q12

Fri Feb 07 00:00:00 UTC 2014

Renal cell carcinomas with t(6;11)(p21;q12): A clinicopathologic study emphasizing unusual morphology, novel alpha-TFEB gene fusion point, immunobiomarkers, and ultrastructural features, as well as detection of the gene fusion by fluorescence in situ hybridization.

The American journal of surgical pathology

Rao Q,Liu B,Cheng L,Zhu Y,Shi QL,Wu B,Jiang SJ,Wang Y,Wang X,Yu B,Zhang RS,Ma HH,Lu ZF,Tu P,Wang JD,Zhou XJ

MA5-14168 was used in immunohistochemistry to perform a detailed clinicopathological study of renal cell carcinomas with t(6;11)(p21;q12)

Sat Sep 01 00:00:00 UTC 2012

Expression of E-cadherin in angiomyolipoma.

Human pathology

Wang Z,Gong Q,Fan Q

MA5-14168 was used in immunohistochemistry to perform a systematic study of E-cadherin expression in angiomyolipoma

Sat Dec 01 00:00:00 UTC 2012

Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review.

Diagnostic pathology

Yin WH,Li J,Chan JK

MA5-14168 was used in immunohistochemistry to report on a case of sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression

Thu Apr 12 00:00:00 UTC 2012

Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

Clay MR,Gibson P,Lowell J,Cooper K

MA5-14168 was used in immunohistochemistry to report a clinical case of microscopic lymphangioleiomyomatosis perivascular epithelioid cell neoplasm in uterus

Sat Jan 01 00:00:00 UTC 2011

Polypoid PEComa in the rectum of a 15-year-old girl: case report and review of PEComa in the gastrointestinal tract.

The American journal of surgical pathology

Ryan P,Nguyen VH,Gholoum S,Carpineta L,Abish S,Ahmed NN,Laberge JM,Riddell RH

MA5-14168 was used in immunohistochemistry to investigate the polypoid PEComa in the gastrointestinal tract

Sun Mar 01 00:00:00 UTC 2009

Diagnostic challenges of metastatic spindle cell melanoma on fine-needle aspiration specimens.

Cancer

Piao Y,Guo M,Gong Y

MA5-14168 was used in immunohistochemistry to review the diagnostic difficulty of metastatic spindle cell melanoma

Fri Apr 25 00:00:00 UTC 2008

Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes.

Journal of cellular physiology

Roberts DW,Newton RA,Leonard JH,Sturm RA

MA5-14168 was used in western blot to study the behavior and functional abilities of melanocytes expressing MC1R red hair color variants

Thu May 01 00:00:00 UTC 2008

Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.

The British journal of dermatology

Willems M,Munte K,Vrolijk JM,Den Hollander JC,Böhm M,Kemmeren MH,De Man RA,Brouwer JT

MA5-14168 was used in immunohistochemistry to study melanin deposition during interferon-alpha therapy for HCV infection

Fri Aug 01 00:00:00 UTC 2003

Acral lentiginous melanoma: an immunohistochemical study of 20 cases.

International journal of dermatology

Kim YC,Lee MG,Choe SW,Lee MC,Chung HG,Cho SH

MA5-14168 was used in immunohistochemistry to identify the diagnostic markers for acral lentiginous melanoma

Sat Feb 01 00:00:00 UTC 2003

Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations.

American journal of clinical pathology

Sheffield MV,Yee H,Dorvault CC,Weilbaecher KN,Eltoum IA,Siegal GP,Fisher DE,Chhieng DC

MA5-14168 was used in immunohistochemistry to study 5 antibodies as diagnostic markers of melanoma incytologic preparation

Sun Dec 01 00:00:00 UTC 2002

Bioinformatics

Protein Aliases: Antigen LB39-AA; Antigen SK29-AA; MART-1; Melanoma antigen recognized by T-cells 1; Protein Melan-A

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Gene Aliases: MART-1; MART1; MLANA

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UniProt ID: (Human) Q16655

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Entrez Gene ID: (Human) 2315

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Function(s)

protein binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Melan-A Monoclonal Antibody (A103)

Melan-A Antibody (MA5-14168) in IHC (P)

Product Details

MA5-14168

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (MISC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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