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Alomone Labs, LTD
Melatonin Receptor 1B (MTNR1B) Polyclonal Antibody
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FIGURE: 1 / 4
Melatonin Receptor 1B (MTNR1B) Antibody (AMR-032-200UL) in IHC (F)
Multiplex staining of Melatonin receptor type 1B and NaV1.2 in rat paraventricular nucleus - Immunohistochemical staining of perfusion-fixed frozen rat paraventricular nucleus sections using Anti-Melatonin Receptor 1B (MTNR1B) Antibody (#AMR-032), (1:600) and Guinea pig Anti-SCN2A (NaV1.2) Antibody (#ASC-002-GP), (1:2000). A. MT2 staining (red) (arrows). B. The same section labeled for NaV1.2 (green). C. Me... View More
Product Details
AMR-032-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RKAKATRKLRLRPSD, corresponding to amino acid residues 232-246 of mouse MTNR1B, 3rd intracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mel-1b melatonin receptor; mel-1B-R; mel1b melatonin receptor; mel1b receptor; melatonin receptor type 1B; MT2 melatonin receptor
Gene Aliases: Mel-1B-R; Mel1b; Mel1b-r; Mt2
Entrez Gene ID: (Rat) 192646, (Mouse) 244701
G-protein coupled receptor signaling pathway
negative regulation of cGMP metabolic process
glucose homeostasis
positive regulation of circadian rhythm
camera-type eye development
negative regulation of neuron apoptotic process
positive regulation of vasodilation
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
regulation of insulin secretion
negative regulation of cytosolic calcium ion concentration
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
regulation of neuronal action potential
negative regulation of delayed rectifier potassium channel activity
signal transduction
circadian rhythm
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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