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Menin Antibody (PA5-86717) in IHC (P)
Immunohistochemical analysis of Menin in paraffin-embedded human lung carcinoma tissue showing nucleus staining and negative control (right). Sample was incubated with polyclonal Menin antibody (Product # PA5-86717) using a 1:50 dilution, and followed by goat anti-rabbit IgG-biotin and avidin-peroxidase secondary antibodies.
Product Details
PA5-86717
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 213-258 of Human Menin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2803477
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Menin; multiple endocrine neoplasia 1; multiple endocrine neoplasia I
Gene Aliases: AW045611; MEAI; MEN1; menin; SCG2
UniProt ID: (Human) O00255, (Mouse) O88559, (Rat) Q9WVR8
Entrez Gene ID: (Human) 4221, (Mouse) 17283, (Rat) 29417
four-way junction DNA binding
Y-form DNA binding
chromatin binding
double-stranded DNA binding
protein binding
histone-lysine N-methyltransferase activity
protein binding, bridging
transcription regulatory region DNA binding
protein N-terminus binding
R-SMAD binding
DNA binding
sequence-specific DNA binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
ossification
leukocyte homeostasis
negative regulation of protein phosphorylation
osteoblast fate commitment
osteoblast development
type B pancreatic cell differentiation
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
cell cycle arrest
negative regulation of cell proliferation
response to UV
embryo development
response to gamma radiation
negative regulation of cell-substrate adhesion
chromatin modification
histone methylation
hemopoiesis
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of histone methylation
positive regulation of protein binding
regulation of activin receptor signaling pathway
histone lysine methylation
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of organ growth
embryonic skeletal system morphogenesis
negative regulation of epithelial cell proliferation
positive regulation of cell division
negative regulation of telomerase activity
palate development
maternal process involved in female pregnancy
regulation of type B pancreatic cell proliferation
response to transforming growth factor beta
negative regulation of cell cycle G1/S phase transition
mitotic cell cycle
brain development
decidualization
cellular response to glucose stimulus
cellular response to peptide hormone stimulus
DNA repair
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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