Proteintech

Midkine Polyclonal Antibody

Midkine Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

Midkine Antibody (11009-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using MDK antibody 11009-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IGG (green).

Midkine Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11009-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:800

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Midkine Fusion Protein Ag1465 (1-143 aa encoded by BC011704)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MQHRGFLLL TLLALLALTS AVAKKKDKVK KGGPGSECAE WAWGPCTPSS KDCGVGFREG TCGAQTQRIR CRVPCNWKKE FGADCKYKFE NWGACDGGTG TKVRQGTLKK ARYNAQCQET IRVTKPCTPK TKAKAKAKKG KGKD (1-143 aa encoded by BC011704)

Target Information

Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.

Brain, behavior, and immunity

Ballasch I,García-García E,Vila C,Pérez-González A,Sancho-Balsells A,Fernández J,Soto D,Puigdellívol M,Gasull X,Alberch J,Rodríguez MJ,Canals JM,Giralt A

Wed Mar 01 00:00:00 UTC 2023

Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line.

Biomedicines

Liu Q,Tan J,Zhao Z,Li R,Zheng L,Chen X,Li L,Dong X,Wen T,Liu J

Wed Dec 21 00:00:00 UTC 2022

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins.

Frontiers in oncology

Zheng L,Liu Q,Li R,Chen S,Tan J,Li L,Dong X,Huang C,Wen T,Liu J

Sat Jul 16 00:00:00 UTC 2022

Roles of the m⁶A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses.

Frontiers in immunology

Yuan F,Cai X,Cong Z,Wang Y,Geng Y,Aili Y,Du C,Zhu J,Yang J,Tang C,Zhang A,Zhao S,Ma C

Tue May 17 00:00:00 UTC 2022

Roles of the m⁶A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses.

Frontiers in immunology

Yuan F,Cai X,Cong Z,Wang Y,Geng Y,Aili Y,Du C,Zhu J,Yang J,Tang C,Zhang A,Zhao S,Ma C

Tue May 17 00:00:00 UTC 2022

Roles of the m⁶A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses.

Frontiers in immunology

Yuan F,Cai X,Cong Z,Wang Y,Geng Y,Aili Y,Du C,Zhu J,Yang J,Tang C,Zhang A,Zhao S,Ma C

Tue May 17 00:00:00 UTC 2022

Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway.

Molecular biology reports

Zhang L,Song L,Xu Y,Xu Y,Zheng M,Zhang P,Wang Q

Fri Apr 01 00:00:00 UTC 2022

Identification of Overexpressed Genes in Malignant Pleural Mesothelioma.

International journal of molecular sciences

Morani F,Bisceglia L,Rosini G,Mutti L,Melaiu O,Landi S,Gemignani F

Mon Mar 08 00:00:00 UTC 2021

Midkine promotes glioblastoma progression via PI3K-Akt signaling.

Cancer cell international

Hu B,Qin C,Li L,Wei L,Mo X,Fan H,Lei Y,Wei F,Zou D

Thu Sep 23 00:00:00 UTC 2021

Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway.

Journal of molecular neuroscience : MN

Xing Y,Yang SD,Wang MM,Dong F,Feng YS,Zhang F

Sat Sep 01 00:00:00 UTC 2018

Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway.

Journal of molecular neuroscience : MN

Xing Y,Yang SD,Wang MM,Dong F,Feng YS,Zhang F

Sat Sep 01 00:00:00 UTC 2018

Mesenchymal glucocorticoid receptor regulates the development of multiple cell layers of the mouse lung.

American journal of respiratory cell and molecular biology

Bird AD,Choo YL,Hooper SB,McDougall AR,Cole TJ

Sat Feb 01 00:00:00 UTC 2014

Mesenchymal glucocorticoid receptor regulates the development of multiple cell layers of the mouse lung.

American journal of respiratory cell and molecular biology

Bird AD,Choo YL,Hooper SB,McDougall AR,Cole TJ

Sat Feb 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Amphiregulin-associated protein; ARAP; FLJ27379; Midgestation and kidney protein; Midkine; MK; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; Retanoic acid-responsive protein; retinoic acid inducible factor; Retinoic acid-induced differentiation factor; retinoic acid-responsive protein

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Gene Aliases: ARAP; MDK; Mek; MK; MK1; NEGF2

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UniProt ID: (Human) P21741, (Mouse) P12025

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Entrez Gene ID: (Human) 4192, (Mouse) 17242

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Function(s)

growth factor activity heparin binding

Process(es)

behavioral fear response multicellular organism development short-term memory response to wounding cell migration cerebellar granular layer development hippocampus development cell differentiation adrenal gland development defecation negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated regulation of behavior positive regulation of cell division negative regulation of neuron death signal transduction Notch signaling pathway nervous system development dentate gyrus development cerebral cortex development response to drug response to glucocorticoid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Midkine Polyclonal Antibody

Midkine Antibody (11009-1-AP) in ICC/IF

Product Details

11009-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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