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Invitrogen
Mig-6 Polyclonal Antibody
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Mig-6 Antibody (PA5-88982) in WB
Western blot analysis of Mig-6 in extracts of Rat lung. Samples were incubated with Mig-6 Polyclonal antibody (Product # PA5-88982) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5 min.
Product Details
PA5-88982
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 223-462 of human ERRFI1 (NP_0618211)
Conjugate
Form
Liquid
Concentration
1.43 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805270
Product Specific Information
Immunogen sequence: SYVSDQNGGV PDPNPPPPQT HRRLRRSHSG PAGSFNKPAI RISNCCIHRA SPNSDEDKPE VPPRVPIPPR PVKPDYRRWS AEVTSSTYSD EDRPPKVPPR EPLSPSNSRT PSPKSLPSYL NGVMPPTQSF APDPKYVSSK ALQRQNSEGS ASKVPCILPI IENGKKVSST HYYLLPERPP YLDKYEKFFR EAEETNGGAQ IQPLPADCGI SSATEKPDSK TKMDLGGHVK RKHLSYVVSP; Positive Samples: Rat lung; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein
Target Information
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERBB receptor feedback inhibitor 1; Gene 33 polypeptide; MIG-6; Mitogen-inducible gene 6 protein homolog; RALT; Receptor-associated late transducer
Gene Aliases: 33; Errfi1; gene 33; Mig6; Ralt; RGD1307599; Xxx
UniProt ID: (Rat) P05432
Entrez Gene ID: (Rat) 313729
negative regulation of epidermal growth factor-activated receptor activity
negative regulation of protein autophosphorylation
negative regulation of interleukin-1 beta production
cellular response to insulin stimulus
negative regulation of collagen biosynthetic process
cellular response to platelet-derived growth factor stimulus
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tumor necrosis factor biosynthetic process
skin morphogenesis
regulation of keratinocyte differentiation
lung alveolus development
negative regulation of peptidyl-tyrosine phosphorylation
lung vasculature development
lung epithelium development
regulation of type B pancreatic cell proliferation
negative regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
cellular hyperosmotic response
cellular response to dexamethasone stimulus
negative regulation of cardiac muscle hypertrophy in response to stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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