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Active Motif
Mili / PiwiL2 Recombinant Mouse Monoclonal Antibody, AbFlex®
Product Details
91253
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG2a
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
This antibody was raised against full length mouse MILI/PIWIL2 (Miwi like/piwi-like 2) recombinant protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
140mM HEPES/32mM sodium acetate, pH 7.5, with 30% glycerol, 70mM NaCl
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2793820
Target Information
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Miwi like; Miwi likw; piwi like homolog 2; PIWI-L2; piwi-like homolog 2; Piwi-like protein 2
Gene Aliases: Mili; Piwil1l; Piwil2
UniProt ID: (Mouse) Q8CDG1
Entrez Gene ID: (Mouse) 57746
pachytene
RNA 5'-end processing
regulation of translation
multicellular organism development
spermatogenesis
cell differentiation
germ-line stem cell population maintenance
gene silencing by RNA
piRNA metabolic process
DNA methylation involved in gamete generation
positive regulation of translation
oogenesis
meiotic cell cycle
positive regulation of meiosis I
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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