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Invitrogen
Monoamine Oxidase B Polyclonal Antibody
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FIGURE: 1 / 8
Monoamine Oxidase B Antibody (PA5-28338) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Monoamine Oxidase B was performed in HepG2 cells fixed in ice cold MeOH for 5 min. Green: Monoamine Oxidase B Polyclonal Antibody (Product # PA5 28338) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-28338
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Monoamine Oxidase B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2545814
Product Specific Information
Recommended positive controls: HepG2, mouse liver.
Predicted reactivity: Mouse (87%), Rat (86%), Dog (94%), Pig (90%), Bovine (90%), Guinea pig (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MAOB (Monoamine Oxidase B), also called MAO, BRAIN, AMINE OXIDASE (FLAVIN-CONTAINING) B, is a protein that in humans is encoded by the MAOB gene. MAOB is a member of the flavin monoamine oxidase family. And it is mapped on Xp11.3. MAOB catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAOA, it also degrades dopamine. MAO-B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviors as well as movement. MAO-B inhibition is, therefore, associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adrenalin oxidase; Amine oxidase [flavin-containing] B; HGNC:6834; MAO b; MAO, brain; MAO, platelet; MAO-B; MGC26382; Monoamine oxidase type B; monoamine oxidase-B; RP1-201D17__B.1; tyramine oxidase
Gene Aliases: 6330414K01Rik; MAO-B; MAOB
UniProt ID: (Human) P27338, (Mouse) Q8BW75, (Rat) P19643
Entrez Gene ID: (Human) 4129, (Mouse) 109731, (Rat) 25750
negative regulation of serotonin secretion
neurotransmitter catabolic process
positive regulation of dopamine metabolic process
oxidation-reduction process
response to toxic substance
response to aluminum ion
response to selenium ion
substantia nigra development
response to lipopolysaccharide
response to drug
response to ethanol
response to steroid hormone
response to corticosterone
dopamine catabolic process
hydrogen peroxide biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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