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Bioss
Musk Monoclonal Antibody (6D1)
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Musk Antibody (BSM-51427M) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse skeletal muscle tissue; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 15 minutes; Blocking buffer (3% BSA) at room temperature for 30min; Antibody incubation with Musk (6D1) Monoclonal Antibody (bsm-51427M) at 1:25 for 1 hour at 37°C, followed by a conjugated secondary antibody ... View More
Product Details
BSM-51427M
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
6D1
Immunogen
This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 40% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126323; MGC126324; muscle localized kinase 2; muscle specific kinase (neural fold/somite kinase 1); Muscle, skeletal receptor tyrosine protein kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine kinase receptor MuSK; Muscle-specific tyrosine protein kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; RP23-170A3.1
Gene Aliases: Mdk4; Mlk; Musk; Nsk1; Nsk2; Nsk3
UniProt ID: (Mouse) Q61006, (Rat) Q62838
Entrez Gene ID: (Mouse) 18198, (Rat) 81725
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
PDZ domain binding
positive regulation of protein phosphorylation
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
multicellular organism development
neuromuscular junction development
memory
regulation of synaptic growth at neuromuscular junction
positive regulation of gene expression
negative regulation of gene expression
phosphorylation
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of synaptic transmission, cholinergic
receptor clustering
positive regulation of neuron apoptotic process
positive regulation of synaptic growth at neuromuscular junction
protein autophosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
response to electrical stimulus
long-term synaptic potentiation
skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein geranylgeranylation
response to muscle activity
response to axon injury
retina development in camera-type eye
cochlea development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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