Invitrogen

Myc Tag Recombinant Mouse Monoclonal Antibody (A3C8-R-2)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-50639

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:10,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse, Tag

Host/Isotype

Mouse / IgG1

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

A3C8-R-2

Immunogen

Synthetic peptide EQKLISEEDL conjugated to keyhole limpet hemocyanin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3092412

Product Specific Information

Positive control: C-terminal Myc-tag fusion protein lysate, N-terminal Myc-tag fusion protein lysate.

Product MA5-50639 was used in an Indirect ELISA.

Target Information

Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 46-0603; c Myc; c-myc epitope tag; c-myc proto-oncogene; cmyc; Myc protein; Myc proto-oncogene protein; Myc Tag; Proto-oncogene c-Myc; R950-25; R95025; Transcription factor p64

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Gene Aliases: AU016757; bHLHe39; Myc; Myc2; Niard; Nird

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UniProt ID: (Mouse) P01108

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Entrez Gene ID: (Mouse) 17869

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein complex binding sequence-specific DNA binding protein heterodimerization activity protein dimerization activity repressing transcription factor binding E-box binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade branching involved in ureteric bud morphogenesis B cell apoptotic process positive regulation of mesenchymal cell proliferation regulation of oxidative phosphorylation positive regulation of B cell apoptotic process glucose metabolic process chromatin remodeling transcription, DNA-templated DNA-templated transcription, initiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter pyruvate transport amino acid transport cellular iron ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus inner mitochondrial membrane organization cell cycle arrest regulation of mitotic cell cycle cell proliferation positive regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage response to radiation response to gamma radiation regulation of gene expression negative regulation of gene expression positive regulation of mitochondrial membrane potential Wnt signaling pathway protein processing transformation of host cell by virus negative regulation of protein binding regulation of telomere maintenance cellular response to drug skeletal muscle cell differentiation middle ear morphogenesis regulation of apoptotic process positive regulation of catalytic activity response to alkaloid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process pigmentation canonical Wnt signaling pathway involved in positive regulation of wound healing canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process negative regulation of monocyte differentiation positive regulation of cell cycle positive regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import lactic acid secretion positive regulation of fibroblast proliferation negative regulation of fibroblast proliferation skeletal system morphogenesis positive regulation of epithelial cell proliferation detection of mechanical stimulus involved in sensory perception of sound chromosome organization negative regulation of cell division canonical Wnt signaling pathway negative regulation of cell death positive regulation of metanephric cap mesenchymal cell proliferation positive regulation of cellular respiration positive regulation of DNA biosynthetic process positive regulation of response to DNA damage stimulus positive regulation of ATP biosynthetic process positive regulation of apoptotic signaling pathway
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