Product References
Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat.
Antioxidants (Basel, Switzerland)
Salagre D,Raya Álvarez E,Cendan CM,Aouichat S,Agil A
14-6503-82 was used in Western Blot to show that melatonin might have potential therapeutic implications for obesity-induced SKM metabolic inflexibility among patients with obesity and T2DM.
Thu Jul 27 00:00:00 UTC 2023
LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1.
iScience
Meng J,Lv Z,Chen X,Sun C,Jin C,Ding K,Chen C
14-6503-82 was used in Western Blotting to reveal that LBP1C-2 might bind to FGFR1 to activate SCs and promote SC self-renewal through Spry1 upregulation.
Fri May 19 00:00:00 UTC 2023
VEGFA Promotes Skeletal Muscle Regeneration in Aging.
Advanced biology
Endo Y,Hwang CD,Zhang Y,Olumi S,Koh DJ,Zhu C,Neppl RL,Agarwal S,Sinha I
14-6503-82 was used in Immunohistochemistry (Paraffin) to suggest that VEGFA may be a therapeutic target in age-related muscle loss.
Sun Oct 01 00:00:00 UTC 2023
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration.
NPJ Regenerative medicine
Xiao C,Hou J,Wang F,Song Y,Zheng J,Luo L,Wang J,Ding W,Zhu X,Xiong JW
14-6503-82 was used in Immunohistochemistry (Paraffin) to demonstrate that the Brg1-Kdm7aa-Notch axis in cardiac endothelial cells, including the endocardium, regulates myocardial proliferation and regeneration via modulating the H3K4me3 of the notch promoters in zebrafish.
Fri Apr 07 00:00:00 UTC 2023
Multiple pkd and piezo gene family members are required for atrioventricular valve formation.
Nature communications
Juan T,Ribeiro da Silva A,Cardoso B,Lim S,Charteau V,Stainier DYR
14-6503-82 was used in Immunohistochemistry to identify, and dissect the role of, several mechanosensors required for AV valve formation, thereby broadening our understanding of cardiac valvulogenesis.
Fri Jan 13 00:00:00 UTC 2023
Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons.
Acta neuropathologica
Jacquier A,Risson V,Simonet T,Roussange F,Lacoste N,Ribault S,Carras J,Theuriet J,Girard E,Grosjean I,Le Goff L,Kröger S,Meltoranta J,Bauché S,Sternberg D,Fournier E,Kostera-Pruszczyk A,O'Connor E,Eymard B,Lochmüller H,Martinat C,Schaeffer L
14-6503-82 was used in Immunocytochemistry-immunoflourescence to report the first mutations in AGRN gene that specifically affect agrin secretion by motoneurons.
Sat Oct 01 00:00:00 UTC 2022
Electroporation of Small Interfering RNAs into Tibialis Anterior Muscles of Mice.
Bio-protocol
Stephan A,Graca FA,Hunt LC,Demontis F
14-6503-82 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to propose a protocol which can help to interrogate gene function in skeletal muscle, by inducing the acute knockdown of the intended target mRNAs in animal models.
Sun Jun 05 00:00:00 UTC 2022
A novel bistable device to study mechanosensitive cell responses to instantaneous stretch.
Biomaterials advances
Choi Y,Morlino G,Toboso-Navasa A,Hopf R,Pramotton FM,Bigot A,Taddei A,Cesarovic N,Falk V,Mazza E,Giampietro C
14-6503-82 was used in Immunocytochemistry to identify a new feature in the mechanoresponse of dystrophic myotubes, which is of potential interest for identifying the diseased cells based on a quick mechanical readout.
Sat Oct 01 00:00:00 UTC 2022
Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation.
Frontiers in cell and developmental biology
Zhang Y,Beketaev I,Ma Y,Wang J
14-6503-82 was used in Immunocytochemistry-immunofluorescence to report that sumoylation mediates Phosphoglycerate mutase 2 activity and is potentially implicated in PGAM2 mutation-linked disease in humans.
Tue Jan 03 00:00:00 UTC 2023
Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve.
Development (Cambridge, England)
Bassen D,Wang M,Pham D,Sun S,Rao R,Singh R,Butcher J
14-6503-82 was used in Immunohistochemistry to demonstrate that compressive/tensile stress regulation of BMP-pSMAD1/5 and MLC2 contractility orchestrates valve growth and remodeling.
Thu Jul 01 00:00:00 UTC 2021
TAM kinase signaling is indispensable for proper skeletal muscle regeneration in mice.
Cell death & disease
Al-Zaeed N,Budai Z,Szondy Z,Sarang Z
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Western Blot
Sat Jun 12 00:00:00 UTC 2021
Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis.
Nature communications
Mantri M,Scuderi GJ,Abedini-Nassab R,Wang MFZ,McKellar D,Shi H,Grodner B,Butcher JT,De Vlaminck I
14-6503-82 was used in Immunohistochemistry to study the spatiotemporal interactions and regulatory programs that drive embryonic chicken heart development using spatially resolved RNA-sequencing with high-throughput single-cell RNA-sequencing.
Fri Mar 19 00:00:00 UTC 2021
Nanopore direct RNA sequencing detects DUX4-activated repeats and isoforms in human muscle cells.
Human molecular genetics
Mitsuhashi S,Nakagawa S,Sasaki-Honda M,Sakurai H,Frith MC,Mitsuhashi H
14-6503-82 was used in Immunocytochemistry, Western Blot, Flow Cytometry to reveal that DUX4 also activates the transcription of repetitive elements such as endogenous retroviruses (ERVs), mammalian apparent long terminal repeat (LTR)-retrotransposons and pericentromeric satellite repeats (Human Satellite II).
Wed May 12 00:00:00 UTC 2021
In vivo detection of programmed cell death during mouse heart development.
Cell death and differentiation
Martínez-Lagunas K,Yamaguchi Y,Becker C,Geisen C,DeRuiter MC,Miura M,Fleischmann BK,Hesse M
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunohistochemistry
Wed Apr 01 00:00:00 UTC 2020
Loss of ARNT in skeletal muscle limits muscle regeneration in aging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Endo Y,Baldino K,Li B,Zhang Y,Sakthivel D,MacArthur M,Panayi AC,Kip P,Spencer DJ,Jasuja R,Bagchi D,Bhasin S,Nuutila K,Neppl RL,Wagers AJ,Sinha I
14-6503 was used in Immunocytochemistry to study loss of aryl hydrocarbon receptor nuclear translocator in skeletal muscle.
Tue Dec 01 00:00:00 UTC 2020
Data on the proliferation and differentiation of C2C12 myoblast treated with branched-chain ketoacid dehydrogenase kinase inhibitor.
Data in brief
Sato Y,Tate H,Yoshizawa F,Sato Y
14-6503 was used in Western Blotting to demonstrate that 1hour treatment of BT2, an inhibitor of BCKDK, decreased the glycolysis of C2C12 differentiated myotubes compared to the control.
Sat Aug 01 00:00:00 UTC 2020
Data on the proliferation and differentiation of C2C12 myoblast treated with branched-chain ketoacid dehydrogenase kinase inhibitor.
Data in brief
Sato Y,Tate H,Yoshizawa F,Sato Y
14-6503 was used in Western Blotting to demonstrate that 1hour treatment of BT2, an inhibitor of BCKDK, decreased the glycolysis of C2C12 differentiated myotubes compared to the control.
Sat Aug 01 00:00:00 UTC 2020
TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice.
Scientific reports
Ono Y,Maejima Y,Saito M,Sakamoto K,Horita S,Shimomura K,Inoue S,Kotani J
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunofluorescence
Mon Jan 20 00:00:00 UTC 2020
TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice.
Scientific reports
Ono Y,Maejima Y,Saito M,Sakamoto K,Horita S,Shimomura K,Inoue S,Kotani J
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunofluorescence
Mon Jan 20 00:00:00 UTC 2020
hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins.
Frontiers in pharmacology
Lamotte JD,Roqueviere S,Gautier H,Raban E,Bouré C,Fonfria E,Krupp J,Nicoleau C
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunocytochemistry
Tue Aug 06 00:00:00 UTC 2024
Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes.
Scientific reports
Testa G,Russo M,Di Benedetto G,Barbato M,Parisi S,Pirozzi F,Tocchetti CG,Abete P,Bonaduce D,Russo T,Passaro F
14-6503 was used in Flow cytometry/Cell sorting to explore the role of Bmi1 inhibitor PTC-209 in the chemically-induced reprogramming of murine cardiac fibroblasts into cardiomyocytes.
Tue Apr 28 00:00:00 UTC 2020
Stable Knockdown of Genes Encoding Extracellular Matrix Proteins in the C2C12 Myoblast Cell Line Using Small-Hairpin (sh)RNA.
Journal of visualized experiments : JoVE
Taye N,Stanley S,Hubmacher D
14-6503-82 was used in Immunocytochemistry to develop a protocol for depletion of extracellular matrix proteins in myoblasts for the study of skeletal muscle development.
Wed Feb 12 00:00:00 UTC 2020
Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome.
Human molecular genetics
Ferre-Fernández JJ,Sorokina EA,Thompson S,Collery RF,Nordquist E,Lincoln J,Semina EV
14-6503-82 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to support a conserved role for foxc1 in the formation of many organs, consistent with the features observed in human patients, and highlight the importance of correct FOXC1/foxc1 dosage for vertebrate development.
Tue Sep 29 00:00:00 UTC 2020
Possible application of muscle specific conditional mouse-derived induced pluripotent stem cells for muscle research.
Biochemistry and biophysics reports
Hosoyama T
14-6503-82 was used in Immunocytochemistry to examine whether homologous recombination was induced in mCM-iPSC-derived myotubes by 4-hydroxytamoxifen (4OH-TAM) administration.
Sun Mar 01 00:00:00 UTC 2020
Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification.
Scientific reports
Pustlauk W,Westhoff TH,Claeys L,Roch T,Geißler S,Babel N
14-6503-82 was used in Immunocytochemistry to comprehensively investigate vascular calcification mechanisms.
Mon Apr 06 00:00:00 UTC 2020
Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells.
Developmental cell
Li S,Karri D,Sanchez-Ortiz E,Jaichander P,Bassel-Duby R,Liu N,Olson EN
14-6503-82 was used in Immunohistochemistry (Frozen) to investigate Sema3a-Nrp1 signaling as a mediator of Tw2+ cell fiber-type specificity.
Mon Oct 07 00:00:00 UTC 2019
IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts.
International journal of molecular sciences
Tokutake Y,Yamada K,Hayashi S,Arai W,Watanabe T,Yonekura S
14-6503-82 was used in Immunocytochemistry to reveal that IRE1-XBP1 signaling plays critical roles in cell viability and the expression of differentiation-related genes in predifferentiated myoblasts and during the early differentiation phase.
Thu Dec 26 00:00:00 UTC 2019
Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations.
Nature communications
Grajcarek J,Monlong J,Nishinaka-Arai Y,Nakamura M,Nagai M,Matsuo S,Lougheed D,Sakurai H,Saito MK,Bourque G,Woltjen K
14-6503 was used in Immunohistochemistry to create pathogenic deletion mutations for demonstrable disease models with both gain- and loss-of-function phenotypes.
Thu Oct 24 00:00:00 UTC 2019
Autologous Cell Therapy Approach for Duchenne Muscular Dystrophy using PiggyBac Transposons and Mesoangioblasts.
Molecular therapy : the journal of the American Society of Gene Therapy
Iyer PS,Mavoungou LO,Ronzoni F,Zemla J,Schmid-Siegert E,Antonini S,Neff LA,Dorchies OM,Jaconi M,Lekka M,Messina G,Mermod N
14-6503-82 was used in Immunohistochemistry (Frozen) to investigate the use of the PiggyBac transposon for full-length dystrophin expression in murine mesoangioblast (MABs) progenitor cells.
Wed Apr 04 00:00:00 UTC 2018
Peptidyl-prolyl cis-trans isomerase NIMA interacting 1 regulates skeletal muscle fusion through structural modification of Smad3 in the linker region.
Journal of cellular physiology
Islam R,Yoon H,Shin HR,Bae HS,Kim BS,Yoon WJ,Woo KM,Baek JH,Lee YS,Ryoo HM
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunocytochemistry
Sat Dec 01 00:00:00 UTC 2018
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
Nature communications
Tsuchiya M,Hara Y,Okuda M,Itoh K,Nishioka R,Shiomi A,Nagao K,Mori M,Mori Y,Ikenouchi J,Suzuki R,Tanaka M,Ohwada T,Aoki J,Kanagawa M,Toda T,Nagata Y,Matsuda R,Takayama Y,Tominaga M,Umeda M
14-6503 was used in Immunocytochemistry to suggest that cell surface flip-flop of phosphatidylserine is a molecular switch for PIEZO1 activation that governs morphogenesis during myotube formation.
Thu May 24 00:00:00 UTC 2018
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
Nature communications
Tsuchiya M,Hara Y,Okuda M,Itoh K,Nishioka R,Shiomi A,Nagao K,Mori M,Mori Y,Ikenouchi J,Suzuki R,Tanaka M,Ohwada T,Aoki J,Kanagawa M,Toda T,Nagata Y,Matsuda R,Takayama Y,Tominaga M,Umeda M
14-6503 was used in Immunocytochemistry to suggest that cell surface flip-flop of phosphatidylserine is a molecular switch for PIEZO1 activation that governs morphogenesis during myotube formation.
Thu May 24 00:00:00 UTC 2018
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Open biology
Kudou K,Komatsu T,Nogami J,Maehara K,Harada A,Saeki H,Oki E,Maehara Y,Ohkawa Y
14-6503 was used in Immunohistochemistry to show that Mettl3 is required for MyoD mRNA expression in proliferative myoblasts.
Fri Sep 01 00:00:00 UTC 2017
Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α.
PloS one
Ono Y,Sakamoto K
14-6503 was used in Western Blotting to suggest that LPS inhibits myogenic differentiation via a TLR4-NF-κB-dependent pathway and an autocrine/paracrine TNF-α-induced pathway.
Fri Sep 29 00:00:00 UTC 2017
FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis.
Cell death & disease
Wang X,Huang N,Yang M,Wei D,Tai H,Han X,Gong H,Zhou J,Qin J,Wei X,Chen H,Fang T,Xiao H
14-6503 was used in Western Blotting to assess the impact of the fat mass- and obesity-associated gene on murine skeletal muscle differentiation.
Thu Mar 23 00:00:00 UTC 2017
Ultrastructure of medial rectus muscles in patients with intermittent exotropia.
Eye (London, England)
Yao J,Wang X,Ren H,Liu G,Lu P
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Western Blot
Fri Jan 01 00:00:00 UTC 2016
Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment.
Integrative biology : quantitative biosciences from nano to macro
Gibson TM,Gersbach CA
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunofluorescence
Mon Jun 01 00:00:00 UTC 2015
Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes.
PloS one
Ifkovits JL,Addis RC,Epstein JA,Gearhart JD
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunofluorescence
Tue Jan 20 00:00:00 UTC 2015
iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes.
Circulation. Cardiovascular genetics
Martinez-Fernandez A,Nelson TJ,Reyes S,Alekseev AE,Secreto F,Perez-Terzic C,Beraldi R,Sung HK,Nagy A,Terzic A
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Flow Cytometry
Wed Oct 01 00:00:00 UTC 2014
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success.
Journal of molecular and cellular cardiology
Addis RC,Ifkovits JL,Pinto F,Kellam LD,Esteso P,Rentschler S,Christoforou N,Epstein JA,Gearhart JD
Published figure using Myosin 4 monoclonal antibody (Product # 14-6503-82) in Immunofluorescence
Mon Jul 01 00:00:00 UTC 2013
