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FIGURE: 1 / 1
N-PAC Antibody (CL488-67340) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human N-PAC (CL488-67340, Clone:1A5E1) and at dilution 1:0 (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67340
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1A5E1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: WQPTASEPVK DADPHFHHFL LSQTEKPAVC YQAITKKLKI CEEETGSTSI QAADSTAVNG SITPTDKKIG FLGLGLMGSG IVSNLLKMGH TVTVWNRTAE KCDLFIQEGA RLGRTPAEVV STCDITFACV SDPKAAKDLV LGPSGVLQGI RPGKCYVDMS TVDADTVTEL AQVIVSRGGR FLEAPVSGNQ QLSNDGMLVI LAAGDRGLYE DCSSCFQAMG KTSFFLGEVG NAAKMMLIVN MVQGSFMATI AEGLTLAQVT GQSQQTLLDI LNQGQLASIF LDQKCQNILQ GNFKPDFYLK YIQKDLRLAI ALGDAVNHPT PMAAAANEVY KRAKALDQSD NDMSAVYRAY IH
Target Information
GLYR1 may have oxidoreductase activity. It regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. It indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. It is recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxyisobutyrate dehydrogenase-like protein; Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; hNDF; NPAC; nuclear protein 60 kDa; nuclear protein 60kDa; Nuclear protein NP60; Nuclear protein of 60 kDa; Nucleosome-destabilizing factor; Putative oxidoreductase GLYR1
Gene Aliases: 2810419J22Rik; 3930401K13Rik; AW545332; BM045; GLYR1; HIBDL; N-PAC; NDF; NP60; NPAC; RGD1309459
UniProt ID: (Human) Q49A26, (Rat) Q5RKH0, (Mouse) Q922P9
Entrez Gene ID: (Human) 84656, (Rat) 360477, (Mouse) 74022
DNA binding
phosphogluconate dehydrogenase (decarboxylating) activity
protein binding
methylated histone binding
NAD binding
N-ethylmaleimide reductase activity
oxidoreductase activity
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
epoxyqueuosine reductase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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