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Invitrogen
N-Ras Monoclonal Antibody (822CT17.5.1)
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Product Details
MA5-37634
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
822CT17.5.1
Immunogen
KLH conjugated synthetic peptide between 70-101 amino acids from the N-terminal region of human NRAS
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897560
Target Information
NRAS (GTPase NRas) is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML) and Noonan syndrome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase NRas; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; RAS; RASN; Transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
Gene Aliases: ALPS4; CMNS; HRAS1; N-ras; NCMS; NRAS; NRAS1; NS6
UniProt ID: (Human) P01111, (Rat) Q04970
Entrez Gene ID: (Human) 4893, (Rat) 24605
MAPK cascade
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
leukocyte migration
establishment of protein localization to Golgi
small GTPase mediated signal transduction
biological_process
positive regulation of cell proliferation
visual learning
actin cytoskeleton organization
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
negative regulation of skeletal muscle tissue development
striated muscle cell differentiation
epithelial tube branching involved in lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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