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Invitrogen
N-sulfated Heparan Sulfate Monoclonal Antibody (HepSS-1), Biotin
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N-sulfated Heparan Sulfate Antibody (MA5-46186) in Flow
Flow Cytometry analysis of N-sulfated Heparan Sulfate using N-sulfated Heparan Sulfate Monoclonal Antibody (HepSS-1), Biotin (Product # MA5-46186). Separation of HUVEC cells (red-filled) from SP2 cells (black-dashed) in flow cytometry analysis (surface staining) stained using Anti-N-sulfated heparan sulfate (HepSS-1) biotin antibody (concentration in sample 12 μg/mL, Streptavidin APC).
Product Details
MA5-46186
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
HepSS-1
Immunogen
MethA murine fibrosarcoma
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
TBS, pH 8
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2937579
Product Specific Information
This antibody recognizes N-sulfated heparan sulfate (extracellular antigen) present in many species.
Target Information
Heparan sulfate (HS) is a glycosaminoglycan that is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane. Each HS molecule is a linear polysaccharide composed of repeating disaccharides of hexuronic acid and d-glucosamine that can exhibit immense structural diversity due to substitution to varying extents with sulfate groups and epimerization of glucuronic acid to iduronic acid, with areas of high sulfation and glucuronic acid epimerization being co-located in hot spots throughout the molecule. HS is structurally related to heparin, an extremely highly sulfated form of HS that is restricted to mast cells. The biosynthesis and modification of HS chains is thought to take place within the endoplasmic reticulum, Golgi apparatus, and trans Golgi network, which in the end produce unique HS chains that are covalently attached to a range of core proteins to form HS-proteoglycans [PMID: 24391644].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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