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Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-NAC protein; Alpha-NAC-like; Hom s 2.01; hom s 2.01 protein; IgE autoantigen alpha-nascent polypeptide-associated complex; NAC-alpha-like; nascent polypeptide-associated complex alpha subunit 2; Nascent polypeptide-associated complex subunit alpha-2; Nascent polypeptide-associated complex subunit alpha-like; nascent polypeptide-associated complex, alpha polypeptide, 2; Prpk; Trp53rk
Gene Aliases: ANAC; NACA2; NACAL
UniProt ID: (Human) Q9H009
Entrez Gene ID: (Human) 342538
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