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Bethyl Laboratories
NACC2/BTBD14A Polyclonal Antibody
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NACC2/BTBD14A Antibody (A304-991A) in WB
Detection of human and mouse NACC2 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-NACC2 antibody (Product # A304-991A) (lot A304-991A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-991A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 175 to 225 of human Nucleus accumbens-associated protein 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BEN domain containing 9; BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; MGC23427; NAC-2; NACC family member 2, BEN and BTB (POZ) domain containing; Nucleus accumbens-associated protein 2; Repressor with BTB domain and BEN domain; transcription repressor with a BTB domain and a BEN domain
Gene Aliases: 0610020I02Rik; AI448087; BEND9; BTBD14; BTBD14A; BTBD31; C030048H19Rik; NAC-2; NAC2; NACC2; RBB
UniProt ID: (Human) Q96BF6, (Mouse) Q9DCM7
Entrez Gene ID: (Human) 138151, (Mouse) 67991
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase activity
protein binding
protein homodimerization activity
histone deacetylase binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
posttranscriptional regulation of gene expression
histone deacetylation
cellular protein complex localization
negative regulation of transcription, DNA-templated
protein homooligomerization
negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
transcription, DNA-templated
positive regulation of cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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