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Invitrogen
NAIP Polyclonal Antibody
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NAIP Antibody (PA5-47935) in WB
Western blot analysis of NAIP in mouse liver tissue and mouse colon tissue. Samples were incubated in NAIP polyclonal antibody (Product # PA5-47935) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for NAIP at approximately 150 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47935
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse NAIP Lys783-Ser856
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576812
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant mouse NAIP2 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: baculoviral IAP repeat-containing 1a; Baculoviral IAP repeat-containing protein 1a; FLJ18088; FLJ42520; FLJ58811; Neuronal apoptosis inhibitory protein 1
Gene Aliases: AV364616; Birc1a; D13Lsd1; Naip; Naip-rs1; Naip1
UniProt ID: (Mouse) Q9QWK5
Entrez Gene ID: (Mouse) 17940
apoptotic process
regulation of signal transduction
negative regulation of peptidase activity
protein ubiquitination
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to estrogen stimulus
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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