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Invitrogen
NAIP Polyclonal Antibody
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FIGURE: 1 / 1
NAIP Antibody (PA5-95853) in WB
Western blot analysis of NAIP in extracts of various cell lines. Samples were incubated with NAIP Polyclonal antibody (Product # PA5-95853) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-95853
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 750-850 of human NAIP (NP_0750431)
Conjugate
Form
Liquid
Concentration
1.34 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807655
Product Specific Information
Immunogen sequence: LLRSIHFPIR GNKTSPRAHF SVLETCFDKS QVPTIDQDYA SAFEPMNEWE RNLAEKEDNV KSYMDMQRRA SPDLSTGYWK LSPKQYKIPC LEVDVNDIDV V
Target Information
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Baculoviral IAP repeat-containing protein 1; FLJ18088; FLJ42520; FLJ58811; Neuronal apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein
Gene Aliases: BIRC1; NAIP; NLRB1; psiNAIP
UniProt ID: (Human) Q13075
Entrez Gene ID: (Human) 4671
apoptotic process
inflammatory response
nervous system development
regulation of signal transduction
protein ubiquitination
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to amino acid
negative regulation of neuron apoptotic process
innate immune response
response to axon injury
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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