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Invitrogen
NALP10 Polyclonal Antibody
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FIGURE: 1 / 2
NALP10 Antibody (PA5-142882) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of NALP10 in NIH3T3 cells using NALP10 Polyclonal Antibody (Product # PA5-142882). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
Product Details
PA5-142882
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence NDLEENSFKTLKFH-C (aa 18-31).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933525
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; neuronal apoptosis inhibitor protein 10
Gene Aliases: 6430548I20Rik; Nalp10; Napl10; Nlrp10; PAN5; Pynod
UniProt ID: (Mouse) Q8CCN1
Entrez Gene ID: (Mouse) 244202
immune system process
positive regulation of T-helper 1 type immune response
defense response
helper T cell enhancement of adaptive immune response
dendritic cell migration
innate immune response
defense response to Gram-negative bacterium
defense response to fungus
positive regulation of T-helper 17 type immune response
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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