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Component of the U1 small nuclear ribonucleoprotein complex (U1 snRNP) involved in the initiation of meiotic recombination (PubMed:1603056, PubMed:7625279). Involved in the formation of DSBs at recombination hot-spots through meiosis-specific splicing of REC107 pre-mRNA (PubMed:7625279, PubMed:9112441, PubMed:21788335). Collaborates with MER1 to promote splicing of essential meiotic mRNAs REC10, AMA1, MER3, HFM1, SPO22 and PCH2 (PubMed:10983980, PubMed:21208980, PubMed:21788335). NAM8 interacts with the pre-mRNA downstream of the 5' splice site, in a region of non-conserved sequence and is required for efficient splicing of uncapped RNA precursor (PubMed:10072385).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MRE2; MUD15; Nam8p; Nuclear accommodation of mitochondria protein 8; Protein NAM8; U1 snRNP component NAM8
Gene Aliases: MRE2; MUD15; NAM8; YHR086W
UniProt ID: (Baker's yeast) Q00539
Entrez Gene ID: (Baker's yeast) 856486
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