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NCAPD2 Antibody (MA5-55418) in WB
Western Blot analysis of various lysates using NCAPD2 Recombinant Monoclonal Antibody (Product # MA5-55418) at 1:1,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
Product Details
MA5-55418
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5E0Q9
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human CNAP1.
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
AB_3667659
Product Specific Information
Immunogen Sequence: LDDTTLSGSD RNAHLNALKM NCYALIRLLE SFETMASQTN LVDLDLGGKG KKARTKAAHG FDWEEERQPI LQLLTQLLQL DIRHLWNHSI IEEEFVSLVT G
Target Information
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromosome condensation related SMC associated protein 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; Condensin complex subunit 1; hCAP-D2; mCAP-D2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; XCAP-D2 homolog
Gene Aliases: 2810406C15Rik; 2810465G24Rik; CAP-D2; CAPD2; CNAP1; hCAP-D2; KIAA0159; mKIAA0159; NCAPD2
UniProt ID: (Human) Q15021, (Mouse) Q8K2Z4
Entrez Gene ID: (Human) 9918, (Mouse) 68298
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