Proteintech

NCBP1 Polyclonal Antibody

NCBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NCBP1 Antibody (10349-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer using 10349-1-AP (NCBP1 antibody) at dilution of 1:100 (under 10x lens).

NCBP1 Antibody in Immunoprecipitation (IP)

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Product Details

10349-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NCBP1 Fusion Protein Ag0496 (46-350 aa encoded by BC001450)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LESNLEGLA GVLEADLPNY KSKILRLLCT VARLLPEKLT IYTTLVGLLN ARNYNFGGEF VEAMIRQLKE SLKANNYNEA VYLVRFLSDL VNCHVIAAPS MVAMFENFVS VTQEEDVPQV RRDWYVYAFL SSLPWVGKEL YEKKDAEMDR IFANTESYLK RRQKTHVPML QVWTADKPHP QEEYLDCLWA QIQKLKKDRW QERHILRPYL AFDSILCEAL QHNLPPFTPP PHTEDSVYPM PRVIFRMFDY TDDPEGPVMP GSHSVERFVI EENLHCIIKS HWKERKTCAA QLVSYPGKNK IPLNYH (46-350 aa encoded by BC001450)

Target Information

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma.

European journal of medical research

Maimaiti A,Feng Z,Liu Y,Turhon M,Xie Z,Baihetiyaer Y,Wang X,Kasimu M,Jiang L,Wang Y,Wang Z,Pei Y

Thu Mar 30 00:00:00 UTC 2023

N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma.

European journal of medical research

Maimaiti A,Feng Z,Liu Y,Turhon M,Xie Z,Baihetiyaer Y,Wang X,Kasimu M,Jiang L,Wang Y,Wang Z,Pei Y

Thu Mar 30 00:00:00 UTC 2023

NCBP1 enhanced proliferation of DLBCL cells via METTL3-mediated m6A modification of c-Myc.

Scientific reports

Meng S,Xia Y,Li M,Wu Y,Wang D,Zhou Y,Ma D,Ye J,Sun T,Ji C

Sat May 27 00:00:00 UTC 2023

RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.

Molecular cell

Li Y,Huang J,Bao L,Zhu J,Duan W,Zheng H,Wang H,Jiang Y,Liu W,Zhang M,Yu Y,Yi C,Ji X

Thu Apr 20 00:00:00 UTC 2023

RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.

Molecular cell

Li Y,Huang J,Bao L,Zhu J,Duan W,Zheng H,Wang H,Jiang Y,Liu W,Zhang M,Yu Y,Yi C,Ji X

Thu Apr 20 00:00:00 UTC 2023

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 UTC 2022

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity.

Neurobiology of disease

An H,Litscher G,Watanabe N,Wei W,Hashimoto T,Iwatsubo T,Buchman VL,Shelkovnikova TA

Sat Jan 01 00:00:00 UTC 2022

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic acids research

Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J

Fri Jun 01 00:00:00 UTC 2018

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic acids research

Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J

Fri Jun 01 00:00:00 UTC 2018

RNA-methylation-dependent RNA processing controls the speed of the circadian clock.

Cell

Fustin JM,Doi M,Yamaguchi Y,Hida H,Nishimura S,Yoshida M,Isagawa T,Morioka MS,Kakeya H,Manabe I,Okamura H

Thu Nov 07 00:00:00 UTC 2013

RNA-methylation-dependent RNA processing controls the speed of the circadian clock.

Cell

Fustin JM,Doi M,Yamaguchi Y,Hida H,Nishimura S,Yoshida M,Isagawa T,Morioka MS,Kakeya H,Manabe I,Okamura H

Thu Nov 07 00:00:00 UTC 2013

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex.

Cancer science

Izumi N,Yamashita A,Hirano H,Ohno S

Sun Jan 01 00:00:00 UTC 2012

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex.

Cancer science

Izumi N,Yamashita A,Hirano H,Ohno S

Sun Jan 01 00:00:00 UTC 2012

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

Science signaling

Izumi N,Yamashita A,Iwamatsu A,Kurata R,Nakamura H,Saari B,Hirano H,Anderson P,Ohno S

Tue Apr 06 00:00:00 UTC 2010

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

Science signaling

Izumi N,Yamashita A,Iwamatsu A,Kurata R,Nakamura H,Saari B,Hirano H,Anderson P,Ohno S

Tue Apr 06 00:00:00 UTC 2010

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

Genes & development

Yamashita A,Izumi N,Kashima I,Ohnishi T,Saari B,Katsuhata Y,Muramatsu R,Morita T,Iwamatsu A,Hachiya T,Kurata R,Hirano H,Anderson P,Ohno S

Fri May 01 00:00:00 UTC 2009

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

Genes & development

Yamashita A,Izumi N,Kashima I,Ohnishi T,Saari B,Katsuhata Y,Muramatsu R,Morita T,Iwamatsu A,Hachiya T,Kurata R,Hirano H,Anderson P,Ohno S

Fri May 01 00:00:00 UTC 2009

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

Genes & development

Yamashita A,Izumi N,Kashima I,Ohnishi T,Saari B,Katsuhata Y,Muramatsu R,Morita T,Iwamatsu A,Hachiya T,Kurata R,Hirano H,Anderson P,Ohno S

Fri May 01 00:00:00 UTC 2009

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

Genes & development

Yamashita A,Izumi N,Kashima I,Ohnishi T,Saari B,Katsuhata Y,Muramatsu R,Morita T,Iwamatsu A,Hachiya T,Kurata R,Hirano H,Anderson P,Ohno S

Fri May 01 00:00:00 UTC 2009

Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.

Molecular cell

Sato H,Hosoda N,Maquat LE

Fri Feb 01 00:00:00 UTC 2008

Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.

Molecular cell

Sato H,Hosoda N,Maquat LE

Fri Feb 01 00:00:00 UTC 2008

Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells.

Methods in enzymology

Matsuda D,Sato H,Maquat LE

Thu Mar 26 00:00:00 UTC 2009

Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells.

Methods in enzymology

Matsuda D,Sato H,Maquat LE

Thu Mar 26 00:00:00 UTC 2009

Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells.

Methods in enzymology

Matsuda D,Sato H,Maquat LE

Thu Mar 26 00:00:00 UTC 2009

Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells.

Methods in enzymology

Matsuda D,Sato H,Maquat LE

Thu Mar 26 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: 80 kDa nuclear cap-binding protein; CBP80; MGC2087; NCBP 80 kDa subunit; nuclear cap binding protein subunit 1, 80kD; nuclear cap binding protein subunit 1, 80kDa; Nuclear cap-binding protein subunit 1; RP11-546O6.1

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Gene Aliases: AU014645; AW538051; CBP80; NCBP; NCBP1; Sto1

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UniProt ID: (Human) Q09161, (Mouse) Q3UYV9

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Entrez Gene ID: (Human) 4686, (Mouse) 433702

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Function(s)

RNA cap binding RNA binding protein binding poly(A) RNA binding

Process(es)

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA splicing, via spliceosome transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter termination of RNA polymerase II transcription 7-methylguanosine mRNA capping RNA export from nucleus mRNA export from nucleus regulation of translational initiation histone mRNA metabolic process RNA splicing fibroblast growth factor receptor signaling pathway gene expression positive regulation of cell growth gene silencing by RNA mRNA 3'-end processing positive regulation of mRNA 3'-end processing snRNA transcription from RNA polymerase II promoter mRNA cis splicing, via spliceosome nuclear export pre-mRNA cleavage required for polyadenylation regulation of mRNA polyadenylation mRNA cleavage mRNA processing regulation of translation transport RNA metabolic process mRNA transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NCBP1 Polyclonal Antibody

NCBP1 Antibody (10349-1-AP) in IHC (P)

Product Details

10349-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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