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Proteintech
NCK1 Polyclonal Antibody
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Product Details
15247-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NCK1 Fusion Protein Ag0979 (84-377 aa encoded by BC006403)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PSVPDSASP ADDSFVDPGE RLYDLNMPAY VKFNYMAERE DELSLIKGTK VIVMEKCSDG WWRGSYNGQV GWFPSNYVTE EGDSPLGDHV GSLSEKLAAV VNNLNTGQVL HVVQALYPFS SSNDEELNFE KGDVMDVIEK PENDPEWWKC RKINGMVGLV PKNYVTVMQN NPLTSGLEPS PPQCDYIRPS LTGKFAGNPW YYGKVTRHQA EMALNERGHE GDFLIRDSES SPNDFSVSLK AQGKNKHFKV QLKETVYCIG QRKFSTMEEL VEHYKKAPIF TSEQGEKLYL VKHLS (84-377 aa encoded by B C006403)
Target Information
NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK adapter protein 1; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; non-catalytic region of tyrosine kinase; non-catalytic region of tyrosine kinase adaptor protein 1; SH2/SH3 adapter protein NCK-alpha; SH2/SH3 adapter protein NCK1; SH2/SH3 adaptor protein NCK-alpha
Gene Aliases: 6330586M15Rik; D230010O13Rik; NCK; Nck-1; NCK1; NCKalpha
UniProt ID: (Human) P16333, (Mouse) Q99M51
Entrez Gene ID: (Human) 4690, (Rat) 300955, (Mouse) 17973
protein kinase inhibitor activity
SH3/SH2 adaptor activity
ARF guanyl-nucleotide exchange factor activity
receptor binding
protein binding
cytoskeletal adaptor activity
protein domain specific binding
receptor signaling complex scaffold activity
protein binding, bridging
receptor tyrosine kinase binding
eukaryotic initiation factor eIF2 binding
cadherin binding involved in cell-cell adhesion
protein kinase regulator activity
negative regulation of protein kinase activity
substrate-dependent cell migration, cell extension
actin filament organization
cell migration
lamellipodium assembly
positive regulation of actin filament polymerization
positive regulation of translation in response to stress
negative regulation of peptidyl-serine phosphorylation
positive regulation of T cell proliferation
T cell activation
positive regulation of transcription from RNA polymerase II promoter
response to other organism
negative regulation of cell death
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
peptidyl-serine dephosphorylation
negative regulation of endoplasmic reticulum unfolded protein response
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of cap-dependent translational initiation
positive regulation of cap-independent translational initiation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
signal complex assembly
vesicle-mediated transport
positive regulation of translation in response to endoplasmic reticulum stress
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
T cell receptor signaling pathway
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
regulation of translation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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