Bioss

NCoR1 Polyclonal Antibody

View all (9) NCoR1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-0224R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NC0R1, amino acids 2301-2400.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-Cor/SMRT corepressor Rip13; N-Cor/SMRT corepressor, Rip13; N-CoR1; NCoR; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1

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Gene Aliases: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1

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UniProt ID: (Human) O75376

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Entrez Gene ID: (Human) 9611, (Rat) 54299, (Mouse) 20185

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Function(s)
RNA polymerase II regulatory region DNA binding RNA polymerase II activating transcription factor binding chromatin binding transcription corepressor activity protein binding ligand-dependent nuclear receptor binding protein domain specific binding estrogen receptor binding nuclear hormone receptor binding histone deacetylase binding peroxisome proliferator activated receptor binding transcription regulatory region DNA binding retinoid X receptor binding thyroid hormone receptor binding DNA binding transcription factor activity, sequence-specific DNA binding histone deacetylase regulator activity retinoic acid receptor binding sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter skeletal muscle tissue development lactation positive regulation of cell proliferation negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling chromatin modification cerebellum development thalamus development regulation of histone deacetylation positive regulation of histone deacetylation circadian regulation of gene expression regulation of multicellular organism growth cholesterol homeostasis negative regulation of transcription, DNA-templated negative regulation of JNK cascade regulation of catalytic activity spindle assembly definitive erythrocyte differentiation regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated transcription from RNA polymerase II promoter circadian rhythm covalent chromatin modification cellular lipid metabolic process negative regulation of production of miRNAs involved in gene silencing by miRNA regulation of fatty acid transport
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