Proteintech

ND5 Polyclonal Antibody

ND5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ND5 Antibody (55410-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 55410-1-AP) (ND5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

55410-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 18 publications 18 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 5 (ND5) is most likely a component of the hydrophobic protein fragment of Complex I. Mutations in the gene encoding for ND5 are implicated in Mitochondrial neurogastrointestinal encephalomyopathy, an autosomal recessive multisystem disorder that results in dramatically elevated levels of circulating thymidine and deoxyuridine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.

The Science of the total environment

Li D,Zhao Q,Xie L,Wang C,Tian Z,Tang H,Xia T,Wang A

Sat Apr 15 00:00:00 UTC 2023

PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.

Toxicological sciences : an official journal of the Society of Toxicology

Tian Z,Li J,Song L,Xie L,Li D,Xia T,Wang A

Tue Jan 31 00:00:00 UTC 2023

Dynamic mapping of proteome trafficking within and between living cells by TransitID.

bioRxiv : the preprint server for biology

Xu WQ,Cheah JS,Xu C,Messing J,Freibaum BD,Boeynaems S,Taylor JP,Udeshi ND,Carr SA,Ting AY

Wed Feb 08 00:00:00 UTC 2023

MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.

iScience

Ji X,Chu L,Su D,Sun J,Song P,Sun S,Wang Y,Mu Q,Liu Y,Wan Q

Fri May 19 00:00:00 UTC 2023

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.

Molecular cell

Jiang B,Zhang J,Zhao G,Liu M,Hu J,Lin F,Wang J,Zhao W,Ma H,Zhang C,Wu C,Yao L,Liu Q,Chen X,Cao Y,Zheng Y,Zhang C,Han A,Lin D,Li Q

Thu May 19 00:00:00 UTC 2022

Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.

The EMBO journal

Shu Y,Hao Y,Feng J,Liu H,Li ST,Feng J,Jiang Z,Ye L,Zhou Y,Sun Y,Zhou Z,Wei H,Gao P,Zhang H,Sun L

Thu Dec 01 00:00:00 UTC 2022

Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.

Free radical biology & medicine

Gu X,Liu Y,Wang N,Zhen J,Zhang B,Hou S,Cui Z,Wan Q,Feng H

Sat Feb 20 00:00:00 UTC 2021

Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.

Mitochondrion

Xie QE,Wang MY,Cao ZP,Du X,Ji DM,Liang D,Cao YX,Liu YJ

Mon Nov 01 00:00:00 UTC 2021

A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.

Cellular and molecular gastroenterology and hepatology

Sun D,Niu Z,Zheng HX,Wu F,Jiang L,Han TQ,Wei Y,Wang J,Jin L

Mon Mar 07 00:00:00 UTC 2022

ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.

Frontiers in cell and developmental biology

Yang Y,Li C,Gu X,Zhen J,Zhu S,Lv T,Wan Q,Liu Y

Fri Aug 27 00:00:00 UTC 2021

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.

Cell metabolism

Wang YP,Sharda A,Xu SN,van Gastel N,Man CH,Choi U,Leong WZ,Li X,Scadden DT

Tue May 04 00:00:00 UTC 2021

MCART1/SLC25A51 is required for mitochondrial NAD transport.

Science advances

Kory N,Uit de Bos J,van der Rijt S,Jankovic N,Güra M,Arp N,Pena IA,Prakash G,Chan SH,Kunchok T,Lewis CA,Sabatini DM

Thu Oct 01 00:00:00 UTC 2020

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.

EMBO reports

Wang C,Richter-Dennerlein R,Pacheu-Grau D,Liu F,Zhu Y,Dennerlein S,Rehling P

Tue Jan 07 00:00:00 UTC 2020

Aging

Ma J,Chen Q,Wang S,Ma R,Jing J,Yang Y,Feng Y,Zou Z,Zhang Y,Ge X,Xue T,Liang K,Cao S,Wang D,Chen L,Yao B

Thu May 07 00:00:00 UTC 2020

SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.

iScience

Ma Y,Zhu S,Lv T,Gu X,Feng H,Zhen J,Xin W,Wan Q

Fri Aug 21 00:00:00 UTC 2020

Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.

Carcinogenesis

Zhuang X,Chen Y,Wu Z,Xu Q,Chen M,Shao M,Cao X,Zhou Y,Xie M,Shi Y,Zeng Y,Bu H

Tue Jul 14 00:00:00 UTC 2020

Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.

Cell death & disease

Fu R,Yang P,Li Z,Liu W,Amin S,Li Z

Wed Aug 07 00:00:00 UTC 2019

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

The EMBO journal

Zhang J,Wang C,Chen X,Takada M,Fan C,Zheng X,Wen H,Liu Y,Wang C,Pestell RG,Aird KM,Kaelin WG,Liu XS,Zhang Q

Wed Dec 02 00:00:00 UTC 2015

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

The EMBO journal

Zhang J,Wang C,Chen X,Takada M,Fan C,Zheng X,Wen H,Liu Y,Wang C,Pestell RG,Aird KM,Kaelin WG,Liu XS,Zhang Q

Wed Dec 02 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: NADH Dehydrogenase 5; NADH dehydrogenase subunit 5; NADH-ubiquinone oxidoreductase chain 5

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Gene Aliases: MT-ND5; MTND5; NADH5; ND5

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UniProt ID: (Mouse) P03921

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Entrez Gene ID: (Mouse) 17721

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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ND5 Polyclonal Antibody

ND5 Antibody (55410-1-AP) in IHC (P)

Product Details

55410-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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