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Product Details
PA5-52674
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NDFIP1. Recombinant protein control fragment (Product #RP-90219).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2644531
Product Specific Information
Immunogen sequence: SRYQQLQNEE ESGEPEQAAG DAPPPYSSIS AESAAYFDYK DESGFPKP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.
Target Information
The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, suggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thought to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies suggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Breast cancer-associated protein SGA-1M; NEDD4 family-interacting protein 1; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein
Gene Aliases: N4WBP5; NDFIP1; PSEC0192; PSEC0223
UniProt ID: (Human) Q9BT67
Entrez Gene ID: (Human) 80762
regulation of myeloid leukocyte differentiation
negative regulation of type 2 immune response
cellular iron ion homeostasis
vacuolar transport
signal transduction
negative regulation of gene expression
metal ion transport
positive regulation of protein ubiquitination
negative regulation of transporter activity
negative regulation of interleukin-4 production
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of lymphocyte differentiation
positive regulation of protein catabolic process
negative regulation of isotype switching to IgE isotypes
regulation of isotype switching to IgG isotypes
negative regulation of inflammatory response
negative regulation of protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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