Proteintech

NDUFS3 Polyclonal Antibody

NDUFS3 Antibody in Immunocytochemistry (ICC/IF)

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NDUFS3 Antibody (15066-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using NDUFS3 antibody (Product # 15066-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

NDUFS3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NDUFS3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15066-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 23 publications 23 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NDUFS3 Fusion Protein Ag7072 (1-264 aa encoded by BC000617)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAAAVARL WWRGILGASA LTRGTGRPSV LLLPVRRESA GADTRPTVRP RNDVAHKQLS AFGEYVAEIL PKYVQQVQVS CFNELEVCIH PDGVIPVLTF LRDHTNAQFK SLVDLTAVDV PTRQNRFEIV YNLLSLRFNS RIRVKTYTDE LTPIESAVSV FKAANWYERE IWDMFGVFFA NHPDLRRILT DYGFEGHPFR KDFPLSGYVE LRYDDEVKRV VAEPVELAQE FRKFDLNSPW EAFPVYRQPP ESLKLEAGDK KPDAK (1-264 aa encoded by BC000617)

Target Information

This gene encodes one of the iron-sulfur protein components of mitochondrial NADH:ubiquinone oxidoreductase. Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.

CNS neuroscience & therapeutics

He JY,Li DD,Wen Q,Qin TY,Long H,Zhang SB,Zhang F

Tue Aug 01 00:00:00 UTC 2023

Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria.

International journal of molecular sciences

Montalvo RN,Boeno FP,Dowllah IM,Moritz CEJ,Nguyen BL,Doerr V,Bomkamp MP,Smuder AJ

Sat Apr 22 00:00:00 UTC 2023

A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H₂S oxidation.

The Journal of biological chemistry

Kumar R,Landry AP,Guha A,Vitvitsky V,Lee HJ,Seike K,Reddy P,Lyssiotis CA,Banerjee R

Sat Jan 01 00:00:00 UTC 2022

Increased COX-1 expression in benign prostate epithelial cells is triggered by mitochondrial dysfunction.

American journal of clinical and experimental urology

Hudson CN,He K,Pascal LE,Liu T,Myklebust LK,Dhir R,Srivastava P,Yoshimura N,Wang Z,Ricke WA,DeFranco DB

Fri May 17 00:00:00 UTC 2024

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins.

Cancer discovery

Santana-Codina N,Del Rey MQ,Kapner KS,Zhang H,Gikandi A,Malcolm C,Poupault C,Kuljanin M,John KM,Biancur DE,Chen B,Das NK,Lowder KE,Hennessey CJ,Huang W,Yang A,Shah YM,Nowak JA,Aguirre AJ,Mancias JD

Fri Sep 02 00:00:00 UTC 2022

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins.

Cancer discovery

Santana-Codina N,Del Rey MQ,Kapner KS,Zhang H,Gikandi A,Malcolm C,Poupault C,Kuljanin M,John KM,Biancur DE,Chen B,Das NK,Lowder KE,Hennessey CJ,Huang W,Yang A,Shah YM,Nowak JA,Aguirre AJ,Mancias JD

Fri Sep 02 00:00:00 UTC 2022

Quercitrin Attenuates Acetaminophen-Induced Acute Liver Injury by Maintaining Mitochondrial Complex I Activity.

Frontiers in pharmacology

Xiong W,Yuan Z,Wang T,Wu S,Xiong Y,Yao Y,Yang Y,Wu H

Wed May 26 00:00:00 UTC 2021

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Investigative ophthalmology & visual science

Jin X,Zhang J,Yi Q,Meng F,Yu J,Ji Y,Mo JQ,Tong Y,Jiang P,Guan MX

Tue Jun 01 00:00:00 UTC 2021

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

The Journal of biological chemistry

Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX

Mon Aug 02 00:00:00 UTC 2021

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

The Journal of biological chemistry

Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX

Mon Aug 02 00:00:00 UTC 2021

SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation.

Life sciences

Xiang Y,Fang B,Liu Y,Yan S,Cao D,Mei H,Wang Q,Hu Y,Guo T

Tue Sep 01 00:00:00 UTC 2020

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.

Molecular cell

Weber RA,Yen FS,Nicholson SPV,Alwaseem H,Bayraktar EC,Alam M,Timson RC,La K,Abu-Remaileh M,Molina H,Birsoy K

Thu Feb 06 00:00:00 UTC 2020

DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice.

Diabetes

Xu X,Wang W,Wang Z,Lv J,Xu X,Xu J,Yang J,Zhu X,Lu Y,Duan W,Huang X,Wang J,Zhou J,Shen X

Tue Sep 01 00:00:00 UTC 2020

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.

The Journal of cell biology

Papadopoulos N,Lennartsson J,Heldin CH

Mon May 07 00:00:00 UTC 2018

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.

The Journal of cell biology

Papadopoulos N,Lennartsson J,Heldin CH

Mon May 07 00:00:00 UTC 2018

The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.

The Journal of biological chemistry

Purandare N,Somayajulu M,Hüttemann M,Grossman LI,Aras S

Fri Apr 27 00:00:00 UTC 2018

The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.

The Journal of biological chemistry

Purandare N,Somayajulu M,Hüttemann M,Grossman LI,Aras S

Fri Apr 27 00:00:00 UTC 2018

Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.

JCI insight

Ryan TE,Yamaguchi DJ,Schmidt CA,Zeczycki TN,Shaikh SR,Brophy P,Green TD,Tarpey MD,Karnekar R,Goldberg EJ,Sparagna GC,Torres MJ,Annex BH,Neufer PD,Spangenburg EE,McClung JM

Fri Nov 02 00:00:00 UTC 2018

Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.

JCI insight

Ryan TE,Yamaguchi DJ,Schmidt CA,Zeczycki TN,Shaikh SR,Brophy P,Green TD,Tarpey MD,Karnekar R,Goldberg EJ,Sparagna GC,Torres MJ,Annex BH,Neufer PD,Spangenburg EE,McClung JM

Fri Nov 02 00:00:00 UTC 2018

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports

Li H,Zhao H,Hao S,Shang L,Wu J,Song C,Meyron-Holtz EG,Qiao T,Li K

Fri Mar 23 00:00:00 UTC 2018

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports

Li H,Zhao H,Hao S,Shang L,Wu J,Song C,Meyron-Holtz EG,Qiao T,Li K

Fri Mar 23 00:00:00 UTC 2018

Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.

Biochimica et biophysica acta. Molecular cell research

Aras S,Arrabi H,Purandare N,Hüttemann M,Kamholz J,Züchner S,Grossman LI

Wed Feb 01 00:00:00 UTC 2017

Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.

Biochimica et biophysica acta. Molecular cell research

Aras S,Arrabi H,Purandare N,Hüttemann M,Kamholz J,Züchner S,Grossman LI

Wed Feb 01 00:00:00 UTC 2017

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Scientific reports

Fu L,Xu Y,Hou Y,Qi X,Zhou L,Liu H,Luan Y,Jing L,Miao Y,Zhao S,Liu H,Li X

Mon Mar 27 00:00:00 UTC 2017

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Scientific reports

Fu L,Xu Y,Hou Y,Qi X,Zhou L,Liu H,Luan Y,Jing L,Miao Y,Zhao S,Liu H,Li X

Mon Mar 27 00:00:00 UTC 2017

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 UTC 2016

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 UTC 2016

The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I.

Scientific reports

Su CY,Chang YC,Yang CJ,Huang MS,Hsiao M

Fri Aug 12 00:00:00 UTC 2016

The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I.

Scientific reports

Su CY,Chang YC,Yang CJ,Huang MS,Hsiao M

Fri Aug 12 00:00:00 UTC 2016

Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.

Scientific reports

Tang H,Li J,Liu X,Wang G,Luo M,Deng H

Tue Jun 21 00:00:00 UTC 2016

Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.

Scientific reports

Tang H,Li J,Liu X,Wang G,Luo M,Deng H

Tue Jun 21 00:00:00 UTC 2016

AIF inhibits tumor metastasis by protecting PTEN from oxidation.

EMBO reports

Shen SM,Guo M,Xiong Z,Yu Y,Zhao XY,Zhang FF,Chen GQ

Sun Nov 01 00:00:00 UTC 2015

AIF inhibits tumor metastasis by protecting PTEN from oxidation.

EMBO reports

Shen SM,Guo M,Xiong Z,Yu Y,Zhao XY,Zhang FF,Chen GQ

Sun Nov 01 00:00:00 UTC 2015

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Mitochondrion

Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI

Thu Jan 01 00:00:00 UTC 2015

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Mitochondrion

Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI

Thu Jan 01 00:00:00 UTC 2015

Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.

Journal of proteomics

Zeng HL,Rao X,Zhang LK,Zhao X,Zhang WP,Wang J,Xu F,Guo L

Tue Sep 23 00:00:00 UTC 2014

Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.

Journal of proteomics

Zeng HL,Rao X,Zhang LK,Zhao X,Zhang WP,Wang J,Xu F,Guo L

Tue Sep 23 00:00:00 UTC 2014

Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats.

Journal of molecular endocrinology

Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

Wed Aug 01 00:00:00 UTC 2012

Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats.

Journal of molecular endocrinology

Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

Wed Aug 01 00:00:00 UTC 2012

Gene expression profiling in glomeruli of diabetic nephropathy rat.

Experimental biology and medicine (Maywood, N.J.)

Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

Wed Aug 01 00:00:00 UTC 2012

Gene expression profiling in glomeruli of diabetic nephropathy rat.

Experimental biology and medicine (Maywood, N.J.)

Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

Wed Aug 01 00:00:00 UTC 2012

Apoptosis-inducing factor is a target gene of C/EBPα and participates in adipocyte differentiation.

FEBS letters

Shen SM,Yu Y,Wu ZX,Zheng Y,Chen GQ,Wang LS

Thu Jul 21 00:00:00 UTC 2011

Apoptosis-inducing factor is a target gene of C/EBPα and participates in adipocyte differentiation.

FEBS letters

Shen SM,Yu Y,Wu ZX,Zheng Y,Chen GQ,Wang LS

Thu Jul 21 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: CI-30kD; complex I 30kDa subunit; Complex I-30kD; NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; NADH dehydrogenase-ubiquinone 30 kDa subunit; NADH-ubiquinone oxidoreductase 30 kDa subunit

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Gene Aliases: 0610010M09Rik; CI-30; CI-30kD; NDUFS3

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UniProt ID: (Human) O75489, (Mouse) Q9DCT2

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Entrez Gene ID: (Human) 4722, (Mouse) 68349, (Rat) 295923

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Function(s)

NADH dehydrogenase activity protein binding NADH dehydrogenase (ubiquinone) activity electron carrier activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H molecular_function

Process(es)

transport negative regulation of cell growth oxidation-reduction process reactive oxygen species metabolic process negative regulation of intrinsic apoptotic signaling pathway mitochondrial electron transport, NADH to ubiquinone substantia nigra development mitochondrial respiratory chain complex I assembly biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NDUFS3 Polyclonal Antibody

NDUFS3 Antibody (15066-1-AP) in ICC/IF

Product Details

15066-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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