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Invitrogen
NEDD8 Monoclonal Antibody (1A7)
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Product Details
MA5-17133
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A7
Immunogen
Purified recombinant fragment of human NEDD8 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538604
Product Specific Information
MA5-17133 targets NEDD8 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17133 immunogen is purified recombinant fragment of human NEDD8 expressed in E. Coli.
MA5-17133 detects NEDD8 which has a predicted molecular weight of approximately 9kDa.
Target Information
NEDD8 is a ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NEDD-8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; Ubiquitin-like protein NEDD8
Gene Aliases: NEDD-8; NEDD8
UniProt ID: (Human) Q6LES6
Entrez Gene ID: (Human) 4738
regulation of transcription from RNA polymerase II promoter
cellular protein modification process
proteolysis
ubiquitin-dependent protein catabolic process
transforming growth factor beta receptor signaling pathway
protein localization
anatomical structure morphogenesis
response to organic cyclic compound
protein neddylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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