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OriGene
NEUROG3 Monoclonal Antibody (OTI3B5), TrueMAB™
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Product Details
CF500346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3B5
Immunogen
Full-length protein expressed in 293T cell transfected with human NEUROG3 expression vector
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Neurog 3 protein contains one basic helix-loop-helix (bHLH) domain.It is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Not only does itinitiates endocrine cell differentiation, italso promotes islet cell maturation and maintains islet function. It is reported that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa7; Class A basic helix-loop-helix protein 7; Neurogenin-3; neurogenin3; NGN-3; Protein atonal homolog 5
Gene Aliases: ATOH5; BHLHA7; Math4B; NEUROG3; NGN-3; NGN3
UniProt ID: (Human) Q9Y4Z2
Entrez Gene ID: (Human) 50674
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator activity
protein binding
chromatin DNA binding
protein dimerization activity
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
central nervous system development
peripheral nervous system development
spinal cord development
epithelial cell differentiation
forebrain development
hindbrain development
endocrine pancreas development
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of dendrite morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
transdifferentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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