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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • NFATC1 Antibodies

          Bioss

          NFAT2 Polyclonal Antibody

          View all (16) NFATC1 antibodies

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          Cite NFAT2 Polyclonal Antibody

          • Antibody Testing Data (3)
          NFAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          NFAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          NFAT2 Antibody (BS-1417R) in IHC (P)

          Formalin-fixed and paraffin embedded mouse lymphoma labeled with Anti-NFATC1/NFAT2 Polyclonal Antibody, Unconjugated (bs-1417R) at 1:200 followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          NFAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          NFAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          NFAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          BS-1417R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:400
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          Flow Cytometry (Flow)

          1:20-1:100
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human NFATc1, amino acids 601-716.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: MGC138448; NF-ATc; NF-ATc1; NFAT tra; NFAT trans; NFAT transcription complex cytosolic component; nuclear factor of activated T-cells 'c'; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor NF-ATc

          View more View less

          Gene Aliases: 2210017P03Rik; AI449492; AV076380; NF-ATC; NF-ATc1.2; NFAT2; NFATC; NFATC1; Nfatcb

          View more View less

          UniProt ID: (Human) O95644

          View more View less

          Entrez Gene ID: (Human) 4772, (Rat) 100361818, (Mouse) 18018

          View more View less

          Function(s)
          RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding FK506 binding mitogen-activated protein kinase p38 binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding
          Process(es)
          G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition lymphangiogenesis B-1a B cell differentiation heart valve morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter calcium ion transport heart development positive regulation of gene expression transition between fast and slow fiber osteoclast differentiation calcineurin-NFAT signaling cascade intracellular signal transduction regulation of hair cycle negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter ventricular septum morphogenesis patterning of lymph vessels heart trabecula morphogenesis negative regulation of stem cell proliferation Wnt signaling pathway, calcium modulating pathway negative regulation of Wnt signaling pathway Fc-epsilon receptor signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated cell quiescence
          It has to be done as per old AB suggested Products section.
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