Product References
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Cellular & molecular biology letters
Yang T,Hei R,Li X,Ma T,Shen Y,Liu C,He W,Zhu L,Gu Y,Hu Y,Wei W,Shen Y
MA3-024 was used in Immunoprecipitation to unmask the new role of NPY2R/NFATc1/DYRK1A in pubertal SG, and are of benefit to advanced understanding the molecular mechanism of SGs' function after puberty.
Thu Jul 27 00:00:00 UTC 2023
Optogenetically engineered Ca2+ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death.
Journal of cell science
Lai YS,Chang CC,Chen YY,Nguyen TMH,Xu J,Chen YC,Chang YF,Wang CY,Chen PS,Lin SC,Peng IC,Tsai SJ,Chiu WT
MA3-024 was used in Western Blotting to provide an effective and innovative approach to altering Ca2+ signaling for controlling mitochondrial fission with a more precise resolution than pharmacological approaches in the temporal dimension.
Thu Jun 15 00:00:00 UTC 2023
MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Experimental & molecular medicine
Hu L,Xie X,Xue H,Wang T,Panayi AC,Lin Z,Xiong Y,Cao F,Yan C,Chen L,Cheng P,Zha K,Sun Y,Liu G,Yu C,Hu Y,Tao R,Zhou W,Mi B,Liu G
MA3-024 was used in Western Blotting to identify miR-1224-5p as a key bone osteogenic regulator, which may be a potential therapeutic target for osteoporosis and fracture nonunion.
Fri Jul 01 00:00:00 UTC 2022
MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Experimental & molecular medicine
Hu L,Xie X,Xue H,Wang T,Panayi AC,Lin Z,Xiong Y,Cao F,Yan C,Chen L,Cheng P,Zha K,Sun Y,Liu G,Yu C,Hu Y,Tao R,Zhou W,Mi B,Liu G
MA3-024 was used in Western Blotting to identify miR-1224-5p as a key bone osteogenic regulator, which may be a potential therapeutic target for osteoporosis and fracture nonunion.
Fri Jul 01 00:00:00 UTC 2022
MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Experimental & molecular medicine
Hu L,Xie X,Xue H,Wang T,Panayi AC,Lin Z,Xiong Y,Cao F,Yan C,Chen L,Cheng P,Zha K,Sun Y,Liu G,Yu C,Hu Y,Tao R,Zhou W,Mi B,Liu G
MA3-024 was used in Western Blotting to identify miR-1224-5p as a key bone osteogenic regulator, which may be a potential therapeutic target for osteoporosis and fracture nonunion.
Fri Jul 01 00:00:00 UTC 2022
Myeloid-derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation.
EMBO reports
Xu X,Li Y,Shi L,He K,Sun Y,Ding Y,Meng B,Zhang J,Xiang L,Dong J,Liu M,Zhang J,Xiang L,Xiang G
MA3-024 was used in ChIP Assay, Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot to conclude that myeloid cell-derived MYDGF is a positive regulator of bone homeostasis by inhibiting bone resorption and promoting bone formation.
Thu Feb 03 00:00:00 UTC 2022
Myeloid-derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation.
EMBO reports
Xu X,Li Y,Shi L,He K,Sun Y,Ding Y,Meng B,Zhang J,Xiang L,Dong J,Liu M,Zhang J,Xiang L,Xiang G
MA3-024 was used in ChIP Assay, Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot to conclude that myeloid cell-derived MYDGF is a positive regulator of bone homeostasis by inhibiting bone resorption and promoting bone formation.
Thu Feb 03 00:00:00 UTC 2022
Cardiac Development in the Presence of Cadmium: An in Vitro Study Using Human Embryonic Stem Cells and Cardiac Organoids.
Environmental health perspectives
Wu X,Chen Y,Luz A,Hu G,Tokar EJ
MA3-024 was used in Immunohistochemistry to provide valuable insights into cellular events and molecular mechanisms associated with Cd-induced congenital heart disease.
Tue Nov 01 00:00:00 UTC 2022
Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement.
Cell proliferation
Wang Q,Xie J,Zhou C,Lai W
MA3-024 was used in Immunocytochemistry to provide evidence proving that extracellular substrate stiffness is a strong determinant of osteoclast differentiation and functions.
Sat Jan 01 00:00:00 UTC 2022
MicroRNA-455-3p regulates proliferation and osteoclast differentiation of RAW264.7 cells by targeting PTEN.
BMC musculoskeletal disorders
Zhang X,Wang L,Huang N,Zheng Y,Cai L,Ke Q,Wu S
MA3-024 was used in Western Blotting to support basic to explore the molecular mechanism of proliferation and osteoblast differentiation of RAW264.7 cells.
Sat Apr 09 00:00:00 UTC 2022
Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
Arteriosclerosis, thrombosis, and vascular biology
Kumar R,Rao GN
MA3-024 was used in Western Blot to reveal that PLCβ3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.
Fri Apr 01 00:00:00 UTC 2022
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Immunity
Xian H,Liu Y,Rundberg Nilsson A,Gatchalian R,Crother TR,Tourtellotte WG,Zhang Y,Aleman-Muench GR,Lewis G,Chen W,Kang S,Luevanos M,Trudler D,Lipton SA,Soroosh P,Teijaro J,de la Torre JC,Arditi M,Karin M,Sanchez-Lopez E
MA3-024 was used in ChIP assay to conclude that inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration.
Tue Jul 13 00:00:00 UTC 2021
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Immunity
Xian H,Liu Y,Rundberg Nilsson A,Gatchalian R,Crother TR,Tourtellotte WG,Zhang Y,Aleman-Muench GR,Lewis G,Chen W,Kang S,Luevanos M,Trudler D,Lipton SA,Soroosh P,Teijaro J,de la Torre JC,Arditi M,Karin M,Sanchez-Lopez E
MA3-024 was used in ChIP assay to conclude that inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration.
Tue Jul 13 00:00:00 UTC 2021
VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis.
Clinical and translational medicine
Lin QY,Zhang YL,Bai J,Liu JQ,Li HH
MA3-024 was used in Western Blotting to demonstrate that activation of the VEGF-C-VEGFR-3 axis exerts a protective effect during the transition from cardiac hypertrophy to HF and highlight selective stimulation of cardiac lymphangiogenesis as a potential new therapeutic approach for hypertrophic heart diseases.
Mon Mar 01 00:00:00 UTC 2021
VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis.
Clinical and translational medicine
Lin QY,Zhang YL,Bai J,Liu JQ,Li HH
MA3-024 was used in Western Blotting to demonstrate that activation of the VEGF-C-VEGFR-3 axis exerts a protective effect during the transition from cardiac hypertrophy to HF and highlight selective stimulation of cardiac lymphangiogenesis as a potential new therapeutic approach for hypertrophic heart diseases.
Mon Mar 01 00:00:00 UTC 2021
Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels.
BMC cancer
Huang J,Hu M,Niu H,Wang J,Si Y,Cheng S,Ding W
MA3-024 was used in Immunocytochemistry to evaluate the effects of conditioned medium from the culture of osteopontin splicing isoforms overexpressing cells on cell functions.
Tue Jun 29 00:00:00 UTC 2021
Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels.
BMC cancer
Huang J,Hu M,Niu H,Wang J,Si Y,Cheng S,Ding W
MA3-024 was used in Immunocytochemistry to evaluate the effects of conditioned medium from the culture of osteopontin splicing isoforms overexpressing cells on cell functions.
Tue Jun 29 00:00:00 UTC 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA3-024 was used in Western Blotting, Immunohistochemistry, and Immunocytochemistry to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 UTC 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA3-024 was used in Western Blotting, Immunohistochemistry, and Immunocytochemistry to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 UTC 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA3-024 was used in Western Blotting, Immunohistochemistry, and Immunocytochemistry to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 UTC 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA3-024 was used in Western Blotting, Immunohistochemistry, and Immunocytochemistry to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 UTC 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA3-024 was used in Western Blotting, Immunohistochemistry, and Immunocytochemistry to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 UTC 2021
DYRK1A activates NFATC1 to increase glioblastoma migration.
Cancer medicine
Liu H,Sun Q,Chen S,Chen L,Jia W,Zhao J,Sun X
MA3-024 was used in Western Blotting, Immunohistochemistry, and Immunocytochemistry to propose that the recovery of NFATC1 stability is a key oncogenic event in a large proportion of gliomas, and pharmacological inhibition of DYRK1A by polypeptides could represent a promising therapeutic intervention for GBM.
Wed Sep 01 00:00:00 UTC 2021
PDGFRα: Expression and Function during Mitral Valve Morphogenesis.
Journal of cardiovascular development and disease
Moore K,Fulmer D,Guo L,Koren N,Glover J,Moore R,Gensemer C,Beck T,Morningstar J,Stairley R,Norris RA
MA3-024 was used in Immunohistochemistry to suggest that PDGFRα functions to suppress mesenchymal transformation and disease phenotypes by stabilizing the valve endocardium through an AKT/ERK pathway.
Sat Mar 13 00:00:00 UTC 2021
Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions.
Arteriosclerosis, thrombosis, and vascular biology
Govatati S,Pichavaram P,Janjanam J,Guo L,Virmani R,Rao GN
MA3-024 was used in Gel Shift to report species-specific regulation of LMCD1 expression in mediating vascular smooth muscle cell proliferation and migration during vascular wall remodeling in humans versus mice.
Fri May 01 00:00:00 UTC 2020
Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Li Q,Wang M,Xue H,Liu W,Guo Y,Xu R,Shao B,Yuan Q
MA3-024 was used in Immunoprecipitation to study the role of Ubiquitin-Specific Protease 34 in the inhibition of Osteoclast Differentiation.
Sat Aug 01 00:00:00 UTC 2020
Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Li Q,Wang M,Xue H,Liu W,Guo Y,Xu R,Shao B,Yuan Q
MA3-024 was used in Immunoprecipitation to study the role of Ubiquitin-Specific Protease 34 in the inhibition of Osteoclast Differentiation.
Sat Aug 01 00:00:00 UTC 2020
Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head.
BioMed research international
Sheng H,Lao Y,Zhang S,Ding W,Lu D,Xu B
MA3-024 was used in Immunocytochemistry-immunoflourescence to evaluate the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluate the efficacy of the combined medicine in regulating the bone resorption and bone regeneration.
Thu Apr 29 00:00:00 UTC 2021
Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head.
BioMed research international
Sheng H,Lao Y,Zhang S,Ding W,Lu D,Xu B
MA3-024 was used in Immunocytochemistry-immunoflourescence to evaluate the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluate the efficacy of the combined medicine in regulating the bone resorption and bone regeneration.
Thu Apr 29 00:00:00 UTC 2021
Cigarette Smoke Extract Activates Tartrate-Resistant Acid Phosphatase-Positive Macrophage.
Journal of vascular research
Igari K,Kelly MJ,Yamanouchi D
MA3-024 was used in Western Blotting to examine the effect of cigarette smoking on osteoclastogenesis (OCG) and arterial aneurysmal formation by using cigarette smoke extract (CSE).
Mon Jan 27 00:00:00 UTC 2020
Calcineurin B1 Deficiency in Glial Cells Induces Mucosal Degeneration and Inflammation in Mouse Small Intestine.
Biological & pharmaceutical bulletin
Fujita M,Yagi T,Okura U,Tanaka J,Hirashima N,Tanaka M
MA3-024 was used in Immunocytochemistry to show the calcineurin B1 deficiency in glial cells impairs the small intestine and leads to malnutrition and eventual death in mice, suggesting that calcineurin plays a novel and important role in enteric glial cells.
Mon Sep 24 00:00:00 UTC 2018
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
International journal of molecular sciences
Pujol JB,Heikkila E,Savoia C,Hajibeigi A,De Marchi U,Battiprolu PK,Öz OK,Dioum EHM
MA3-024 was used in Western Blotting to investigate the role of Isx9 in Β-cell survival.
Mon Aug 27 00:00:00 UTC 2018
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
International journal of molecular sciences
Pujol JB,Heikkila E,Savoia C,Hajibeigi A,De Marchi U,Battiprolu PK,Öz OK,Dioum EHM
MA3-024 was used in Western Blotting to investigate the role of Isx9 in Β-cell survival.
Mon Aug 27 00:00:00 UTC 2018
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
International journal of molecular sciences
Pujol JB,Heikkila E,Savoia C,Hajibeigi A,De Marchi U,Battiprolu PK,Öz OK,Dioum EHM
MA3-024 was used in Western Blotting to investigate the role of Isx9 in Β-cell survival.
Mon Aug 27 00:00:00 UTC 2018
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
International journal of molecular sciences
Pujol JB,Heikkila E,Savoia C,Hajibeigi A,De Marchi U,Battiprolu PK,Öz OK,Dioum EHM
MA3-024 was used in Western Blotting to investigate the role of Isx9 in Β-cell survival.
Mon Aug 27 00:00:00 UTC 2018
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue.
EMBO reports
Hui X,Zhang M,Gu P,Li K,Gao Y,Wu D,Wang Y,Xu A
MA3024 was used in western blot to clarify the roles of SIRT1 in adipose tissues
Sat Apr 01 00:00:00 UTC 2017
Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload.
American journal of physiology. Cell physiology
Fajardo VA,Rietze BA,Chambers PJ,Bellissimo C,Bombardier E,Quadrilatero J,Tupling AR
MA3-024 was used in Western Blotting to show that SLN plays an important role in adaptive muscle remodelling potentially through calcineurin stimulation.
Tue Aug 01 00:00:00 UTC 2017
p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.
The Journal of biological chemistry
Singh NK,Janjanam J,Rao GN
MA3-024 was used in Western Blotting to identify the RhoGEFs involved in monocyte chemotactic protein 1-induced vascular wall remodelling.
Fri Aug 25 00:00:00 UTC 2017
p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.
The Journal of biological chemistry
Singh NK,Janjanam J,Rao GN
MA3-024 was used in Western Blotting to identify the RhoGEFs involved in monocyte chemotactic protein 1-induced vascular wall remodelling.
Fri Aug 25 00:00:00 UTC 2017
p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.
The Journal of biological chemistry
Singh NK,Janjanam J,Rao GN
MA3-024 was used in Western Blotting to identify the RhoGEFs involved in monocyte chemotactic protein 1-induced vascular wall remodelling.
Fri Aug 25 00:00:00 UTC 2017
p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.
The Journal of biological chemistry
Singh NK,Janjanam J,Rao GN
MA3-024 was used in Western Blotting to identify the RhoGEFs involved in monocyte chemotactic protein 1-induced vascular wall remodelling.
Fri Aug 25 00:00:00 UTC 2017
NFATc1 phosphorylation by DYRK1A increases its protein stability.
PloS one
Liu H,Wang K,Chen S,Sun Q,Zhang Y,Chen L,Sun X
MA3024 was used in western blot to find DYRK1A increases NFATc1/alphaA protein levels and subsequent transcriptional activity
Mon Aug 21 00:00:00 UTC 2017
Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
PloS one
Fajardo VA,Gamu D,Mitchell A,Bloemberg D,Bombardier E,Chambers PJ,Bellissimo C,Quadrilatero J,Tupling AR
MA3024 was used in western blot to report the physiological role of sarcolipin upregulation in muscle myopathy
Wed Sep 06 00:00:00 UTC 2017
Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.
The Journal of biological chemistry
Kotla S,Singh NK,Kirchhofer D,Rao GN
MA3-024 was used in Western Blotting to investigate the role of 12/15-lipoxygenase in tissue factor expression.
Fri Sep 08 00:00:00 UTC 2017
GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation.
Nature communications
Liu W,Zhou L,Zhou C,Zhang S,Jing J,Xie L,Sun N,Duan X,Jing W,Liang X,Zhao H,Ye L,Chen Q,Yuan Q
MA3-024 was used in immunohistochemistry - paraffin section and western blot to study the role of GDF11 in bone remodeling
Thu Sep 22 00:00:00 UTC 2016
GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation.
Nature communications
Liu W,Zhou L,Zhou C,Zhang S,Jing J,Xie L,Sun N,Duan X,Jing W,Liang X,Zhao H,Ye L,Chen Q,Yuan Q
MA3-024 was used in immunohistochemistry - paraffin section and western blot to study the role of GDF11 in bone remodeling
Thu Sep 22 00:00:00 UTC 2016
Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers.
Brain and behavior
Fajardo VA,Smith IC,Bombardier E,Chambers PJ,Quadrilatero J,Tupling AR
MA3-024 was used in western blot to study slow-twitch type 1 muscle fibers and diaphragm assessment in mice overexpressing phospholamban
Wed Jun 01 00:00:00 UTC 2016
The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.
PLoS genetics
Keller MP,Paul PK,Rabaglia ME,Stapleton DS,Schueler KL,Broman AT,Ye SI,Leng N,Brandon CJ,Neto EC,Plaisier CL,Simonett SP,Kebede MA,Sheynkman GM,Klein MA,Baliga NS,Smith LM,Broman KW,Yandell BS,Kendziorski C,Attie AD
MA3024 was used in western blot to discuss the role of NFAT in type II diabetes
Thu Dec 01 00:00:00 UTC 2016
Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation.
Biochemical and biophysical research communications
Hajibeigi A,Dioum EM,Guo J,Öz OK
MA3-024 was used in ChIP assay to identify novel components for regulation called NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation
Fri Sep 25 00:00:00 UTC 2015
Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells.
Bioscience, biotechnology, and biochemistry
Tang Y,Abe N,Yoshimoto M,Zhu B,Murata Y,Nakamura Y
MA3-024 was used in Western Blotting to study the mechanism by which benzyl isothiocyanate inhibits interleukin-13 expression in human basophilic KU812 cells.
Tue Oct 06 00:00:00 UTC 2015
Counter-regulation of T cell effector function by differentially activated p38.
The Journal of experimental medicine
Alam MS,Gaida MM,Ogawa Y,Kolios AG,Lasitschka F,Ashwell JD
MA3-024 was used in western blot to describe mechanisms of p38 activation that converge on NFATc1 and result in opposing effects on T cell immunity
Mon Jun 02 00:00:00 UTC 2014
Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients.
PLoS pathogens
Tourneur E,Ben Mkaddem S,Chassin C,Bens M,Goujon JM,Charles N,Pellefigues C,Aloulou M,Hertig A,Monteiro RC,Girardin SE,Philpott DJ,Rondeau E,Elbim C,Werts C,Vandewalle A
MA3-024 was used in immunocytochemistry to study the downregulation of Nod1 expression by cyclosprine A in a murine model of acute pyelonephritis and in renal transplant patients
Tue Jan 01 00:00:00 UTC 2013
Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall remodeling.
The Journal of biological chemistry
Kundumani-Sridharan V,Singh NK,Kumar S,Gadepalli R,Rao GN
MA3-024 was used in immunocytochemistry and western blot to study the roles of NFATc1 and Pak1 in chemokine-induced aortic smooth muscle proliferation and vascular remodeling following injury
Fri Jul 26 00:00:00 UTC 2013
The effect of the degree of sulfation of glycosaminoglycans on osteoclast function and signaling pathways.
Biomaterials
Salbach J,Kliemt S,Rauner M,Rachner TD,Goettsch C,Kalkhof S,von Bergen M,Möller S,Schnabelrauch M,Hintze V,Scharnweber D,Hofbauer LC
MA3-024 was used in western blot to study the effects of manufactured native and sulfated glycosaminoglycans on osteoblast function and signaling, and the significance for biomaterial use
Thu Nov 01 00:00:00 UTC 2012
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.
Journal of autoimmunity
Hermann-Kleiter N,Meisel M,Fresser F,Thuille N,Müller M,Roth L,Katopodis A,Baier G
ma3-024 was used in EMSA to study the role of the NR2F6 orphan nuclear receptor in modulating Il17a transcription by antagonizing the promoter binding of RORgamma-t and NFAT
Sat Dec 01 00:00:00 UTC 2012
STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
Molecular and cellular biology
Li T,Finch EA,Graham V,Zhang ZS,Ding JD,Burch J,Oh-hora M,Rosenberg P
MA3-024 was used in western blot to study hypertrophic murine skeletal muscle growth and the essential role of STIM1 regulated Ca(2+) signaling
Wed Aug 01 00:00:00 UTC 2012
Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.
The Journal of biological chemistry
Singh NK,Kundumani-Sridharan V,Kumar S,Verma SK,Kotla S,Mukai H,Heckle MR,Rao GN
Published figure using NFATC1 monoclonal antibody (Product # MA3-024) in Western Blot
Fri Oct 19 00:00:00 UTC 2012
Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.
The Journal of biological chemistry
Singh NK,Kundumani-Sridharan V,Kumar S,Verma SK,Kotla S,Mukai H,Heckle MR,Rao GN
Published figure using NFATC1 monoclonal antibody (Product # MA3-024) in Western Blot
Fri Oct 19 00:00:00 UTC 2012
Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.
The Journal of biological chemistry
Kundumani-Sridharan V,Van Quyen D,Subramani J,Singh NK,Chin YE,Rao GN
MA3-024 was used in ChIP assay to study the role of NFATc1 and STAT3 in mediating the expression of cyclin D1
Fri Jun 29 00:00:00 UTC 2012
The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.
Molecular and cellular biology
Chan MC,Weisman AS,Kang H,Nguyen PH,Hickman T,Mecker SV,Hill NS,Lagna G,Hata A
MA3-024 was used in immunoprecipitation to investigate the effect of constitutive elevation of Trb3 on IPAH and FPAH therapy
Tue Feb 01 00:00:00 UTC 2011
The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.
Molecular and cellular biology
Chan MC,Weisman AS,Kang H,Nguyen PH,Hickman T,Mecker SV,Hill NS,Lagna G,Hata A
MA3-024 was used in immunoprecipitation to investigate the effect of constitutive elevation of Trb3 on IPAH and FPAH therapy
Tue Feb 01 00:00:00 UTC 2011
Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation.
Molecular biology of the cell
Wang Q,Zhou Y,Jackson LN,Johnson SM,Chow CW,Evers BM
MA3-024 was used in western blot to confirm the role of NFATc1 in PTEN expression and intestinal cell differentiation
Tue Feb 01 00:00:00 UTC 2011
NFATc1 regulation of TRAIL expression in human intestinal cells.
PloS one
Wang Q,Zhou Y,Weiss HL,Chow CW,Evers BM
MA3-024 was used in EMSA to investigate the regulatory effect of NFATc1 on TRAIL in human intestinal cells
Fri Oct 21 00:00:00 UTC 2011
The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4.
The Journal of biological chemistry
Oh M,Dey A,Gerard RD,Hill JA,Rothermel BA
MA3-024 was used in immunoprecipitation to investigate the role of the CCAAT/enhancer binding protein beta during calcineurin/NFAT activation of RCAN1-4 expression
Fri May 28 00:00:00 UTC 2010
The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4.
The Journal of biological chemistry
Oh M,Dey A,Gerard RD,Hill JA,Rothermel BA
MA3-024 was used in immunoprecipitation to investigate the role of the CCAAT/enhancer binding protein beta during calcineurin/NFAT activation of RCAN1-4 expression
Fri May 28 00:00:00 UTC 2010
The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4.
The Journal of biological chemistry
Oh M,Dey A,Gerard RD,Hill JA,Rothermel BA
MA3-024 was used in immunoprecipitation to investigate the role of the CCAAT/enhancer binding protein beta during calcineurin/NFAT activation of RCAN1-4 expression
Fri May 28 00:00:00 UTC 2010
Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling.
The Journal of biological chemistry
Karpurapu M,Wang D,Van Quyen D,Kim TK,Kundumani-Sridharan V,Pulusani S,Rao GN
MA3-024 was used in western blot to show the expression of NFATc1 is inhibited in HASMCs transfected with NFATc1 siRNA
Fri Jan 29 00:00:00 UTC 2010
Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling.
The Journal of biological chemistry
Karpurapu M,Wang D,Van Quyen D,Kim TK,Kundumani-Sridharan V,Pulusani S,Rao GN
MA3-024 was used in western blot to show the expression of NFATc1 is inhibited in HASMCs transfected with NFATc1 siRNA
Fri Jan 29 00:00:00 UTC 2010
Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling.
The Journal of biological chemistry
Karpurapu M,Wang D,Van Quyen D,Kim TK,Kundumani-Sridharan V,Pulusani S,Rao GN
MA3-024 was used in western blot to show the expression of NFATc1 is inhibited in HASMCs transfected with NFATc1 siRNA
Fri Jan 29 00:00:00 UTC 2010
Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling.
The Journal of biological chemistry
Karpurapu M,Wang D,Van Quyen D,Kim TK,Kundumani-Sridharan V,Pulusani S,Rao GN
MA3-024 was used in western blot to show the expression of NFATc1 is inhibited in HASMCs transfected with NFATc1 siRNA
Fri Jan 29 00:00:00 UTC 2010
FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
Journal of immunology (Baltimore, Md. : 1950)
Torgerson TR,Genin A,Chen C,Zhang M,Zhou B,Añover-Sombke S,Frank MB,Dozmorov I,Ocheltree E,Kulmala P,Centola M,Ochs HD,Wells AD,Cron RQ
MA3-024 was used in chromatin immunoprecipitation to study the effect of FOXP3 on NFAT-mediated inflammatory gene expression.
Wed Jul 15 00:00:00 UTC 2009
FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.
Journal of immunology (Baltimore, Md. : 1950)
Torgerson TR,Genin A,Chen C,Zhang M,Zhou B,Añover-Sombke S,Frank MB,Dozmorov I,Ocheltree E,Kulmala P,Centola M,Ochs HD,Wells AD,Cron RQ
MA3-024 was used in chromatin immunoprecipitation to study the effect of FOXP3 on NFAT-mediated inflammatory gene expression.
Wed Jul 15 00:00:00 UTC 2009
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.
Immunity
Matza D,Badou A,Kobayashi KS,Goldsmith-Pestana K,Masuda Y,Komuro A,McMahon-Pratt D,Marchesi VT,Flavell RA
MA3-024 was used in western blot to investigate the role of AHNAK1 in calcium signaling during T cell activation
Tue Jan 01 00:00:00 UTC 2008
Increased oxidative properties of gastrocnemius in rats fed on a high-protein diet.
The Journal of nutritional biochemistry
Nakazato K,Song H
MA3-024 was used in western blot to investigate the effect of high-protein diet on the expression of NFATc1 in gastrocnemius muscles
Tue Jan 01 00:00:00 UTC 2008
Glycogen synthase kinase 3beta regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury.
Experimental cell research
Chow W,Hou G,Bendeck MP
MA3-024 was used in western blot to study the effect of glycogen synthase kinase 3beta on NFATc1 in the vascular smooth muscle cell response to injury
Wed Oct 01 00:00:00 UTC 2008
NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis.
The Journal of biological chemistry
Karpurapu M,Wang D,Singh NK,Li Q,Rao GN
MA3-024 was used in chromatin immunoprecipitation and western blot to study the role of NFATc1 in vascular smooth muscle cell multiplication during restenosis.
Fri Sep 26 00:00:00 UTC 2008
NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis.
The Journal of biological chemistry
Karpurapu M,Wang D,Singh NK,Li Q,Rao GN
MA3-024 was used in chromatin immunoprecipitation and western blot to study the role of NFATc1 in vascular smooth muscle cell multiplication during restenosis.
Fri Sep 26 00:00:00 UTC 2008
Calcineurin-mediated slow-type fiber expression and growth in reloading condition.
Medicine and science in sports and exercise
Miyazaki M,Hitomi Y,Kizaki T,Ohno H,Katsumura T,Haga S,Takemasa T
MA3-024 was used in western blot to study the role of calcineurin in muscle growth and muscle type determination
Thu Jun 01 00:00:00 UTC 2006
Defective IgG2a/2b class switching in PKC alpha-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Pfeifhofer C,Gruber T,Letschka T,Thuille N,Lutz-Nicoladoni C,Hermann-Kleiter N,Braun U,Leitges M,Baier G
MA3-024 was used in western blot to study the effect of PKC alpha deletion on IgG2a/2b class switching
Mon May 15 00:00:00 UTC 2006
Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers.
Molecular biology of the cell
Shen T,Liu Y,Cseresnyés Z,Hawkins A,Randall WR,Schneider MF
MA3-024 was used in immunocytochemistry to investigate the nucleocytoplasmic shuttling of NFATc1.
Sat Apr 01 00:00:00 UTC 2006
Hypertrophy and transcriptional regulation induced in myogenic cell line L6-C5 by an increase of extracellular calcium.
Journal of cellular physiology
De Arcangelis V,Coletti D,Canato M,Molinaro M,Adamo S,Reggiani C,Naro F
MA3-024 was used in western blot to investigate the effect of calcium concentration on cell growth and gene expresion in myogenic cell line L6-C5
Tue Mar 01 00:00:00 UTC 2005
2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2.
Journal of leukocyte biology
Kaplan BL,Ouyang Y,Rockwell CE,Rao GK,Kaminski NE
MA3-024 was used in western blot to study the effect of 2-arachidonoyl-glycerol on interferon-gamma in mouse splenocytes
Wed Jun 01 00:00:00 UTC 2005
Activation of the Ca(2+)/calcineurin/NFAT2 pathway controls smooth muscle cell differentiation.
Experimental cell research
Larrieu D,Thiébaud P,Duplàa C,Sibon I,Thézé N,Lamazière JM
MA3-024 was used in immunocytochemistry and western blot to study the role of Ca(2+)/calcineurin/NFAT2 pathway activation in regulating smooth muscle cell differentiation
Sat Oct 15 00:00:00 UTC 2005
Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model.
The Journal of biological chemistry
Liu Z,Zhang C,Dronadula N,Li Q,Rao GN
MA3-024 was used in western blot to demonstrate the role of nuclear factor of activated T cells in neointima formation.
Fri Apr 15 00:00:00 UTC 2005
Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model.
The Journal of biological chemistry
Liu Z,Zhang C,Dronadula N,Li Q,Rao GN
MA3-024 was used in western blot to demonstrate the role of nuclear factor of activated T cells in neointima formation.
Fri Apr 15 00:00:00 UTC 2005
Calcium-dependent activation of interleukin-21 gene expression in T cells.
The Journal of biological chemistry
Kim HP,Korn LL,Gamero AM,Leonard WJ
MA3-024 was used in EMSA to demonstrate the induction of the IL-21 in preactivated T lymphocytes by a calcium signal.
Fri Jul 01 00:00:00 UTC 2005
TRPC3 channels confer cellular memory of recent neuromuscular activity.
Proceedings of the National Academy of Sciences of the United States of America
Rosenberg P,Hawkins A,Stiber J,Shelton JM,Hutcheson K,Bassel-Duby R,Shin DM,Yan Z,Williams RS
MA3-024 was used in western blot to study the regulation of NFAT functions through neuromuscular stimulation in rodent skeletal muscles.
Tue Jun 22 00:00:00 UTC 2004
NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching.
Proceedings of the National Academy of Sciences of the United States of America
McCullagh KJ,Calabria E,Pallafacchina G,Ciciliot S,Serrano AL,Argentini C,Kalhovde JM,Lømo T,Schiaffino S
MA3-024 was used in immunohistochemistry to study the role of NFAT in activity-dependent fiber type specification in skeletal muscle.
Tue Jul 20 00:00:00 UTC 2004
Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production.
Journal of immunology (Baltimore, Md. : 1950)
Cannon JL,Burkhardt JK
MA3-024 was used in western blot to investigate the role of Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production
Sun Aug 01 00:00:00 UTC 2004
Contribution of the calcineurin signaling pathway to overload-induced skeletal muscle fiber-type transition.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Miyazaki M,Hitomi Y,Kizaki T,Ohno H,Haga S,Takemasa T
MA3-024 was used in western blot to study the role of the calcineurin signaling pathway during overload-induced skeletal muscle fiber-type transition
Wed Dec 01 00:00:00 UTC 2004
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.
The Journal of experimental medicine
Pfeifhofer C,Kofler K,Gruber T,Tabrizi NG,Lutz C,Maly K,Leitges M,Baier G
MA3-024 was used in western blot to study the role of protein kinase C theta in calcium mobilization and NFAT activation in mouse T cells.
Mon Jun 02 00:00:00 UTC 2003
Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway.
American journal of physiology. Cell physiology
Dupont-Versteegden EE,Knox M,Gurley CM,Houlé JD,Peterson CA
MA3-024 was used in immunohistochemistry to study the role of the calcineurin-NFAT pathway in the maintenance of muscle mass
Sat Jun 01 00:00:00 UTC 2002
Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.
Molecular pharmacology
Jan TR,Rao GK,Kaminski NE
MA3-024 was used in EMSA assay to investigate the mechanism of cannabinol enhancement of interleukin-2 (IL-2) expression by CBN in T cells
Fri Feb 01 00:00:00 UTC 2002
A potential role for nuclear factor of activated T-cells in receptor tyrosine kinase and G-protein-coupled receptor agonist-induced cell proliferation.
The Biochemical journal
Yellaturu CR,Ghosh SK,Rao RK,Jennings LK,Hassid A,Rao GN
MA3-024 was used in EMSA to investigate the role of NFATs in receptor tyrosine kinase and GRCR agonist-induced proliferation of vascular smooth muscle cells
Fri Nov 15 00:00:00 UTC 2002
Double-stranded RNA regulates IL-4 expression.
Journal of immunology (Baltimore, Md. : 1950)
Kehoe KE,Brown MA,Imani F
MA3-024 was used in EMSA to investigate the role of the low concentrations of dsRNA towards the IL-4 expression.
Sat Sep 01 00:00:00 UTC 2001
Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.
Biochemical and biophysical research communications
Mukerjee N,McGinnis KM,Gnegy ME,Wang KK
MA3-024 was used in western blot to study the role of NFATc in interleukin-2 transactivation
Fri Aug 03 00:00:00 UTC 2001
The calcineurin-NFAT pathway and muscle fiber-type gene expression.
American journal of physiology. Cell physiology
Swoap SJ,Hunter RB,Stevenson EJ,Felton HM,Kansagra NV,Lang JM,Esser KA,Kandarian SC
MA3-024 was used in western blot to investigate the role of calcineurin-NFAT pathway in the regulation of muscle fiber-type gene expression
Sun Oct 01 00:00:00 UTC 2000
c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.
Molecular and cellular biology
Chow CW,Dong C,Flavell RA,Davis RJ
MA3-024 was used in immunocytochemistry to examine the role of JNK1 in NFATc1 regulation.
Sat Jul 01 00:00:00 UTC 2000
Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients.
International immunology
Wierenga EA,Walchner M,Kick G,Kapsenberg ML,Weiss EH,Messer G
MA3-024 was used in EMSA assay to study why IL-4 gene is upregulated in atopy
Mon Feb 01 00:00:00 UTC 1999
Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter.
Journal of immunology (Baltimore, Md. : 1950)
Li-Weber M,Salgame P,Hu C,Davydov IV,Laur O,Klevenz S,Krammer PH
MA3-024 was used in EMSA assay to study the mechanism for the function of human IL-4
Sat Aug 01 00:00:00 UTC 1998
Histamine induces nuclear factor of activated T cell-mediated transcription and cyclosporin A-sensitive interleukin-8 mRNA expression in human umbilical vein endothelial cells.
Molecular pharmacology
Boss V,Wang X,Koppelman LF,Xu K,Murphy TJ
MA3-024 was used in western blot to study the roles of histamine during NFAT-mediated transcription
Sat Aug 01 00:00:00 UTC 1998
Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.
The Journal of biological chemistry
Li-Weber M,Giasi M,Krammer PH
MA3-024 was used in EMSA assay to study the mechanism for the effect of CD28 on interleukin-4 gene function
Fri Dec 04 00:00:00 UTC 1998
The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface receptors.
The Journal of biological chemistry
Boss V,Abbott KL,Wang XF,Pavlath GK,Murphy TJ
MA3-024 was used in western blot to demonstrate the differential localization of NFAT isoforms expressed in vascular smooth muscle cells
Fri Jul 31 00:00:00 UTC 1998
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
Science (New York, N.Y.)
Chow CW,Rincón M,Cavanagh J,Dickens M,Davis RJ
MA3-024 was used in immunohistochemistry to demonstrate that nuclear accumulation of NFAT4 is regulated by JNK
Fri Nov 28 00:00:00 UTC 1997
Expression of NFAT-family proteins in normal human T cells.
Molecular and cellular biology
Lyakh L,Ghosh P,Rice NR
MA3-024 was used in EMSA assay to investigate the expression levels of various NFAT proteins in normal human T cells
Thu May 01 00:00:00 UTC 1997
Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells.
The Journal of biological chemistry
Latinis KM,Norian LA,Eliason SL,Koretzky GA
MA3-024 was used in EMSA assay to investigate the regulation of CD95 expression by NFAT
Fri Dec 12 00:00:00 UTC 1997
