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Product Details
H00084901-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NFATC2IP (AAH21551.1, 1 a.a. approximately 138 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSEPLQSVVD HMATHLGVSP SRILLLFGET ELSPTATPRT LKLGVADIID CVVLTSSPEA TETSQQLQLR VQGKEKHQTL EVSLSRDSPL KTLMSHYEEA MGLSGRKLSF FFDGTKLSGR ELPADLGMES GDLIEVWG
Target Information
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; NFATC2-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
Gene Aliases: ESC2; NFATC2IP; NIP45; RAD60
UniProt ID: (Human) Q8NCF5
Entrez Gene ID: (Human) 84901
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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