Proteintech

NFATC3 Polyclonal Antibody

NFATC3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NFATC3 Antibody (18222-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis using 18222-1-AP (NFATC3 antibody) at dilution of 1:100 (under 40x lens).

NFATC3 Antibody in Immunoprecipitation (IP)

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Product Details

18222-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

ChIP assay (ChIP)

Assay-dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NFATC3 Fusion Protein Ag12985 (1-205 aa encoded by BC001050)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTTANCGAH DELDFKLVFG EDGAPAPPPP GSRPADLEPD DCASIYIFNV DPPPSTLTTP LCLPHHGLPS HSSVLSPSFQ LQSHKNYEGT CEIPESKYSP LGGPKPFECP SIQITSISPN CHQELDAHED DLQINDPERE FLERPSRDHL YLPLEPSYRE SSLSPSPASS ISSRSWFSDA SSCESLSHIY DDVDSELNEA AARFTL (1-205 aa encoded by B C001050)

Target Information

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Blocking Store-Operated Ca²⁺ Entry to Protect HL-1 Cardiomyocytes from Epirubicin-Induced Cardiotoxicity.

Cells

Liu X,Chang Y,Choi S,Cai C,Zhang X,Pan Z

Fri Feb 24 00:00:00 UTC 2023

miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells.

Acta biochimica et biophysica Sinica

Li Y,Long Y,Zhi X,Hao H,Wang X,Liu H,Wang L

Sat Feb 25 00:00:00 UTC 2023

Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.

Pharmacological research

Li X,Zhang Y,Zhao Y,Zhou Y,Han Q,Yang Y,Zhang L,Shi L,Jin X,Zhang R,Gao H,Xue G,Li D,Zhang ZR,Lu Y,Yang B,Pan Z

Mon Aug 01 00:00:00 UTC 2022

Pou3f1 mediates the effect of Nfatc3 on ulcerative colitis-associated colorectal cancer by regulating inflammation.

Cellular & molecular biology letters

Lin Y,Wang D,Zhao H,Li D,Li X,Lin L

Mon Sep 05 00:00:00 UTC 2022

Pou3f1 mediates the effect of Nfatc3 on ulcerative colitis-associated colorectal cancer by regulating inflammation.

Cellular & molecular biology letters

Lin Y,Wang D,Zhao H,Li D,Li X,Lin L

Mon Sep 05 00:00:00 UTC 2022

Trim39 regulates neuronal apoptosis by acting as a SUMO-targeted E3 ubiquitin-ligase for the transcription factor NFATc3.

Cell death and differentiation

Basu-Shrivastava M,Mojsa B,Mora S,Robbins I,Bossis G,Lassot I,Desagher S

Tue Nov 01 00:00:00 UTC 2022

Trim39 regulates neuronal apoptosis by acting as a SUMO-targeted E3 ubiquitin-ligase for the transcription factor NFATc3.

Cell death and differentiation

Basu-Shrivastava M,Mojsa B,Mora S,Robbins I,Bossis G,Lassot I,Desagher S

Tue Nov 01 00:00:00 UTC 2022

Substitution of SERCA2 Cys⁶⁷⁴ aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts.

Biochemical pharmacology

Huang X,Lin X,Wang L,Xie Y,Que Y,Li S,Hu P,Tong X

Thu Sep 01 00:00:00 UTC 2022

Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy.

European journal of pharmacology

Tian J,Shan XL,Wang SN,Chen HH,Zhao P,Qian DD,Xu M,Guo W,Zhang C,Lu R

Wed Jan 05 00:00:00 UTC 2022

A-kinase anchoring protein 5-ancored calcineurin regulates the remodeling of H9c2 cardiomyocytes exposed to hypoxia and reoxygenation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhu F,Yuan C,Zhang X,Wang Z,Wang Q,Wang H

Tue Nov 01 00:00:00 UTC 2022

TARBP2-stablized SNHG7 regulates blood-brain barrier permeability by acting as a competing endogenous RNA to miR-17-5p/NFATC3 in Aβ-microenvironment.

Cell death & disease

Ning H,Zhang L,Zhu B,Zhou X,Zhang T,Ma T

Fri May 13 00:00:00 UTC 2022

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.

Immunity

Xian H,Liu Y,Rundberg Nilsson A,Gatchalian R,Crother TR,Tourtellotte WG,Zhang Y,Aleman-Muench GR,Lewis G,Chen W,Kang S,Luevanos M,Trudler D,Lipton SA,Soroosh P,Teijaro J,de la Torre JC,Arditi M,Karin M,Sanchez-Lopez E

Tue Jul 13 00:00:00 UTC 2021

TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.

Cancer letters

Lin DC,Zheng SY,Zhang ZG,Luo JH,Zhu ZL,Li L,Chen LS,Lin X,Sham JSK,Lin MJ,Zhou RX

Thu Oct 28 00:00:00 UTC 2021

Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells.

Oncogene

Lao M,Zhang X,Ma T,Xu J,Yang H,Duan Y,Ying H,Zhang X,Guo C,Qiu J,Bai X,Liang T

Thu Apr 01 00:00:00 UTC 2021

The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hatano S,Matsuda S,Okanobu A,Furutama D,Memida T,Kajiya M,Ouhara K,Fujita T,Mizuno N,Kurihara H

Thu Jul 01 00:00:00 UTC 2021

The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hatano S,Matsuda S,Okanobu A,Furutama D,Memida T,Kajiya M,Ouhara K,Fujita T,Mizuno N,Kurihara H

Thu Jul 01 00:00:00 UTC 2021

Transmembrane Protein Ttyh1 Maintains the Quiescence of Neural Stem Cells Through Ca²⁺/NFATc3 Signaling.

Frontiers in cell and developmental biology

Cao Y,Wu HN,Cao XL,Yue KY,Han WJ,Cao ZP,Zhang YF,Gao XY,Luo C,Jiang XF,Han H,Zheng MH

Thu Apr 04 00:00:00 UTC 2024

Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.

Journal of diabetes research

Wang Q,Tian X,Zhou W,Wang Y,Zhao H,Li J,Zhou X,Zhang H,Zhao T,Li P

Mon Aug 23 00:00:00 UTC 2021

NFATc3 regulation of collagen V expression contributes to cellular immunity to collagen type V and hypoxic pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Sheak JR,Jones DT,Lantz BJ,Maston LD,Vigil D,Resta TC,Resta MM,Howard TA,Kanagy NL,Guo Y,Jankowska-Gan E,Sullivan JA,Braun RK,Burlingham WJ,Gonzalez Bosc LV

Tue Dec 01 00:00:00 UTC 2020

NFATc3 regulation of collagen V expression contributes to cellular immunity to collagen type V and hypoxic pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Sheak JR,Jones DT,Lantz BJ,Maston LD,Vigil D,Resta TC,Resta MM,Howard TA,Kanagy NL,Guo Y,Jankowska-Gan E,Sullivan JA,Braun RK,Burlingham WJ,Gonzalez Bosc LV

Tue Dec 01 00:00:00 UTC 2020

Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1.

JBMR plus

Sogi C,Takeshita N,Jiang W,Kim S,Maeda T,Yoshida M,Oyanagi T,Ito A,Kimura S,Seki D,Takano I,Sakai Y,Fujiwara I,Kure S,Takano-Yamamoto T

Wed Jul 01 00:00:00 UTC 2020

Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition.

Cellular signalling

Lin Y,Koumba MH,Qu S,Wang D,Lin L

Thu Oct 01 00:00:00 UTC 2020

The calcium pump PMCA4 prevents epithelial-mesenchymal transition by inhibiting NFATc1-ZEB1 pathway in gastric cancer.

Biochimica et biophysica acta. Molecular cell research

Wang T,Li N,Jin L,Qi X,Zhang C,Hua D

Tue Dec 01 00:00:00 UTC 2020

Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.

European journal of pharmacology

Zheng J,Tian J,Wang S,Hu P,Wu Q,Shan X,Zhao P,Zhang C,Guo W,Xu M,Chen H,Lu R

Tue Sep 15 00:00:00 UTC 2020

Tsantan Sumtang Restored Right Ventricular Function in Chronic Hypoxia-Induced Pulmonary Hypertension Rats.

Frontiers in pharmacology

Yang Z,Sun H,Su S,Nan X,Li K,Jin X,Jin G,Li Z,Lu D

Sat Feb 06 00:00:00 UTC 2021

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

He RL,Wu ZJ,Liu XR,Gui LX,Wang RX,Lin MJ

Tue Sep 18 00:00:00 UTC 2018

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

He RL,Wu ZJ,Liu XR,Gui LX,Wang RX,Lin MJ

Tue Sep 18 00:00:00 UTC 2018

TRPV2-induced Ca²⁺-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Cell communication and signaling : CCS

Bai H,Zhu H,Yan Q,Shen X,Lu X,Wang J,Li J,Chen L

Tue Oct 16 00:00:00 UTC 2018

TRPV2-induced Ca²⁺-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Cell communication and signaling : CCS

Bai H,Zhu H,Yan Q,Shen X,Lu X,Wang J,Li J,Chen L

Tue Oct 16 00:00:00 UTC 2018

TRPV2-induced Ca²⁺-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Cell communication and signaling : CCS

Bai H,Zhu H,Yan Q,Shen X,Lu X,Wang J,Li J,Chen L

Tue Oct 16 00:00:00 UTC 2018

TRPV2-induced Ca²⁺-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Cell communication and signaling : CCS

Bai H,Zhu H,Yan Q,Shen X,Lu X,Wang J,Li J,Chen L

Tue Oct 16 00:00:00 UTC 2018

Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1.

Gastroenterology

Jin H,Wang C,Jin G,Ruan H,Gu D,Wei L,Wang H,Wang N,Arunachalam E,Zhang Y,Deng X,Yang C,Xiong Y,Feng H,Yao M,Fang J,Gu J,Cong W,Qin W

Fri Sep 01 00:00:00 UTC 2017

Gastroenterology

Jin H,Wang C,Jin G,Ruan H,Gu D,Wei L,Wang H,Wang N,Arunachalam E,Zhang Y,Deng X,Yang C,Xiong Y,Feng H,Yao M,Fang J,Gu J,Cong W,Qin W

Fri Sep 01 00:00:00 UTC 2017

Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells.

Molecular biology of the cell

Zhou Y,Wang Q,Guo Z,Weiss HL,Evers BM

Wed Aug 01 00:00:00 UTC 2012

Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells.

Molecular biology of the cell

Zhou Y,Wang Q,Guo Z,Weiss HL,Evers BM

Wed Aug 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: NF-AT4; NF-ATc3; NFAC3; NFATx; NFC3; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4

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Gene Aliases: C80703; D8Ertd281e; NFAT4; NFATC3; NFATX

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UniProt ID: (Human) Q12968

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Entrez Gene ID: (Human) 4775, (Mouse) 18021

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor binding sequence-specific DNA binding

Process(es)

regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response Fc-epsilon receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter negative regulation of pri-miRNA transcription from RNA polymerase II promoter patterning of blood vessels response to hypoxia blood vessel remodeling transcription, DNA-templated regulation of transcription, DNA-templated heart development cardiac muscle hypertrophy in response to stress myotube differentiation myotube cell development T cell differentiation calcineurin-NFAT signaling cascade cellular respiration positive regulation of transcription, DNA-templated thymus development skeletal muscle fiber development smooth muscle cell differentiation muscle cell development cellular response to calcium ion cellular response to lithium ion regulation of store-operated calcium entry

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NFATC3 Polyclonal Antibody

NFATC3 Antibody (18222-1-AP) in IHC (P)

Product Details

18222-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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