Invitrogen

NFATC3 Polyclonal Antibody

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View all (15) NFATC3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99546

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
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Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NFATC3(Accession Q12968), corresponding to amino acid residues E139-Y189.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818479

Product Specific Information

Antibody detects endogenous levels of total NFAT4.

Target Information

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: NF-AT4; NF-ATc3; NFAC3; NFATx; NFC3; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4

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Gene Aliases: C80703; D8Ertd281e; NFAT4; NFATC3; NFATX

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UniProt ID: (Human) Q12968

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Entrez Gene ID: (Human) 4775, (Mouse) 18021

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor binding sequence-specific DNA binding
Process(es)
regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response Fc-epsilon receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter negative regulation of pri-miRNA transcription from RNA polymerase II promoter patterning of blood vessels response to hypoxia blood vessel remodeling transcription, DNA-templated regulation of transcription, DNA-templated heart development cardiac muscle hypertrophy in response to stress myotube differentiation myotube cell development T cell differentiation calcineurin-NFAT signaling cascade cellular respiration positive regulation of transcription, DNA-templated thymus development skeletal muscle fiber development smooth muscle cell differentiation muscle cell development cellular response to calcium ion cellular response to lithium ion regulation of store-operated calcium entry
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