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NeoBiotechnologies
NFIA/NF1A (Nuclear Factor 1A) (Transcription Factor) Monoclonal Antibody (PCRP-NFIA-2C6)
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Product Details
4774-MSM2-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2c, kappa
Class
Monoclonal
Type
Antibody
Clone
PCRP-NFIA-2C6
Immunogen
Recombinant fragment of human NFIA protein corresponding to protein domain
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCAAT-box-binding transcription factor; CTF; NF-I/A; NF1-A; NFI-A; Nuclear factor 1 A-type; nuclear factor 1/A; Nuclear factor I/A; TGGCA-binding protein
Gene Aliases: 1110047K16Rik; 9430022M17Rik; CTF; KIAA1439; NF-I/A; NF1-A; NF1A; Nf1l21; NFI-A; NFI-L; NFIA
UniProt ID: (Human) Q12857, (Rat) P09414, (Mouse) Q02780
Entrez Gene ID: (Human) 4774, (Rat) 25492, (Mouse) 18027
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription from RNA polymerase II promoter
response to organic cyclic compound
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
synapse maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
viral genome replication
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