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Invitrogen
NFIB Monoclonal Antibody (1H2)
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Product Details
MA5-34902
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1H2
Immunogen
Recombinant protein within Human NFIB/NF1B2 aa 1-420
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848808
Product Specific Information
Positive Control: SH-SY-5Y, LO-2, rat heart tissue, human colon cancer tissue, human prostate tissue, human pancreas tissue, mouse liver tissue.
Target Information
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; Nuclear factor 1 B-type; nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein
Gene Aliases: CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB; NFIB2; NFIB3
UniProt ID: (Human) O00712
Entrez Gene ID: (Human) 4781
chondrocyte differentiation
DNA replication
transcription from RNA polymerase II promoter
glial cell differentiation
principal sensory nucleus of trigeminal nerve development
anterior commissure morphogenesis
hindbrain development
positive regulation of transcription from RNA polymerase II promoter
Clara cell differentiation
Type I pneumocyte differentiation
Type II pneumocyte differentiation
salivary gland cavitation
cell differentiation involved in salivary gland development
lung ciliated cell differentiation
commissural neuron axon guidance
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of mesenchymal cell proliferation involved in lung development
negative regulation of epithelial cell proliferation involved in lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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