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Invitrogen
NFKBID Polyclonal Antibody
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Product Details
PA5-49695
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to a region derived from 1-221 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2635148
Product Specific Information
The antibody detects endogenous level of total NFKBID protein.
Target Information
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.I-kappa-BNS, the nuclear I-kappa-B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.I-kappa-BNS has been identified as a member of the I-kappa-B family of NF-kappa-B inhibitors, which undergoes induction upon TCR signaling. I-kappa-BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: I-kappa-B-delta; ikappaBdelta; IkappaBNS; IkB-delta; NF-kappa-B inhibitor delta; NFKB inhibitor delta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta; T-cell activation NFKB-like protein; TA-NFKBH
Gene Aliases: IkappaBNS; IKBNS; NFKBID; TA-NFKBH
UniProt ID: (Human) Q8NI38
Entrez Gene ID: (Human) 84807
regulation of transcription from RNA polymerase II promoter
inflammatory response
negative regulation of NF-kappaB transcription factor activity
negative regulation of T cell differentiation in thymus
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of thymocyte apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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