Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
26273-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NFKBIL1 Fusion Protein Ag21978 (100-381 aa encoded by BC105064)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TALHAAARQ GPDAYTDFFL PLLSRCPSAM GIKNKDGETP GQILGWGPPW DSAEEEEEDD ASKEREWRQK LQGELEDEWQ EVMGRFEGDA SHETQEPESF SAWSDRLARE HAQKCQQQQR EAEGSCRPPR AEGSSQSWRQ QEEEQRLFRE RARAKEEELR ESRARRAQEA LGDREPKPTR AGPREEHPRG AGRGSLWRFG DVPWPCPGGG DPEAMAAALV ARGPPLEEQG ALRRYLRVQQ VRWHPDRFLQ RFRSQIETWE LGRVMGAVTA LSQALNRHAE ALK (100-381 aa encoded by BC105064)
Target Information
NF-kappa-B inhibitor-like protein 1 (NFKBIL1), also named Ikb like and IkbL1, is a 381 amino acid member of the inhibitor of NF-kappaB (IkappaB) family of proteins. NFKBIL1 contains two ANK repeats and is expressed in the rheumatoid synovial lining and sub-lining layers and co-localized in CD68+ and CD3+, but not Factor VIII+ cells. It is reported that defects in NFKBIL1 expression causes of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and affects the joints. Rheumatoid arthritis (RA) is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: DADB-70P7.2; I-kappa-B-like protein; ikappaBL; Inhibitor of kappa B-like protein; NF-kappa-B inhibitor-like protein 1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Gene Aliases: IKBL; LST1; NFKBIL; NFKBIL1
UniProt ID: (Human) Q9UBC1
Entrez Gene ID: (Human) 4795
I-kappaB kinase/NF-kappaB signaling
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
cytoplasmic sequestering of transcription factor
cellular response to lipopolysaccharide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support