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Immunogen sequence: PAAAFRSPLA RQLFRIEGVK SVFFGPDFIT VTKENEELDW NLLKPDIYAT IMDFFASGLP LVTEETPSGE AGSEEDD
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 99%.
This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIRA-interacting protein 5; iron-sulfur cluster scaffold protein; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; NifU-like C-terminal domain containing
Gene Aliases: CGI-33; HIRIP; HIRIP5; MMDS1; Nfu; NFU1; NifU; NIFUC
UniProt ID: (Human) Q9UMS0
Entrez Gene ID: (Human) 27247
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