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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: HIRA-interacting protein 5; histone cell cycle regulation defective interacting protein 5; iron-sulfur cluster scaffold protein; mHIRIP5; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; NifU-like C-terminal domain containing
Gene Aliases: 0610006G17Rik; CGI-33; HIRIP; HIRIP5; MMDS1; Nfu; NFU1; NifU; NIFUC
UniProt ID: (Human) Q9UMS0, (Mouse) Q9QZ23
Entrez Gene ID: (Human) 27247, (Rat) 297416, (Mouse) 56748
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