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Product Details
16387-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NFX1 Fusion Protein Ag9448 (771-1120 aa encoded by BC012151)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TCARVHECD HPVYHSCHSE EKCPPCTFLT QKWCMGKHEF RSNIPCHLVD ISCGLPCSAT LPCGMHKCQR LCHKGECLVD EPCKQPCTTP RADCGHPCMA PCHTSSPCPV TACKAKVELQ CECGRRKEMV ICSEASSTYQ RIAAISMASK ITDMQLGGSV EISKLITKKE VHQARLECDE ECSALERKKR LAEAFHISED SDPFNIRSSG SKFSDSLKED ARKDLKFVSD VEKEMETLVE AVNKGKNSKK SHSFPPMNRD HRRIIHDLAQ VYGLESVSYD SEPKRNVVVT AIRGKSVCPP TTLTGVLERE MQARPPPPIP HHRHQSDKNP GSSNLQKITK EPIIDYFDVQ D (771-1120 aa encoded by BC012151)
Target Information
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp779G2416; m-Nfx.1; MGC20369; Nuclear transcription factor, X box-binding protein 1; testis expressed gene 42; Transcriptional repressor NF-X1; X-box binding 1
Gene Aliases: 1300017N15Rik; 3000003M19Rik; NFX.1; NFX1; NFX2; TEG-42; Tex42
UniProt ID: (Human) Q12986, (Mouse) B1AY10
Entrez Gene ID: (Human) 4799, (Rat) 313166, (Mouse) 74164
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
ligase activity
poly(A) RNA binding
nucleic acid binding
DNA binding
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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