Proteintech

NGB Polyclonal Antibody

NGB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NGB Antibody (13499-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer using 13499-1-AP (NGB antibody) at dilution of 1:100 (under 40x lens).

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Product Details

13499-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NGB Fusion Protein Ag4325 (1-151 aa encoded by BC032509)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MERPEPELI RQSWRAVSRS PLEHGTVLFA RLFALEPDLL PLFQYNCRQF SSPEDCLSSP EFLDHIRKVM LVIDAAVTNV EDLSSLEEYL ASLGRKHRAV GVKLSSFSTV GESLLYMLEK CLGPAFTPAT RAAWSQLYGA VVQAMSRGWD GE (1-151 aa encoded by BC032509)

Target Information

Globins are a superfamily of gas-binding heme proteins that are present in bacteria, protists, fungi, plants and animals. Globins play evolutionarily divergent roles which include binding, transport, scavenging, detoxification, and sensing of oxygen, nitric oxide and carbon monoxide. Neuroglobin (Ngb) is a hexacoordinate hemoglobin that is predominantly expressed in the vertebrate brain and may enhance oxygen supply to neural components. Neuroglobin displays a high affinity for oxygen and its presence in cerebral neurons suggests a role in neuronal responses to hypoxia or ischemia. For example, in vitro neuronal hypoxia causes an elevation in the levels of neuroglobin, which enhances neuronal cell survival. The human neuroglobin gene maps to chromosome 14q24 and encodes a 151 amino acid protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats.

Anatomical record (Hoboken, N.J. : 2007)

Hu JH,Fan P,Zhang LR,Chen CY,Xu J,Huang J,Lu WT,Zhu SJ,Qiu GP,Xu SY,Ran JH,Gan SW

Tue Feb 01 00:00:00 UTC 2022

Prunus cerasoides Extract and Its Component Compounds Upregulate Neuronal Neuroglobin Levels, Mediate Antioxidant Effects, and Ameliorate Functional Losses in the Mouse Model of Cerebral Ischemia.

Antioxidants (Basel, Switzerland)

Kim SD,Kim M,Wu HH,Jin BK,Jeon MS,Song YS

Thu Dec 30 00:00:00 UTC 2021

Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq.

Diabetes

Wang Y,Niu A,Pan Y,Cao S,Terker AS,Wang S,Fan X,Toth CL,Ramirez Solano MA,Michell DL,Contreras D,Allen RM,Zhu W,Sheng Q,Fogo AB,Vickers KC,Zhang MZ,Harris RC

Fri Oct 01 00:00:00 UTC 2021

Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway.

Life sciences

Yang F,Zhang Y,Tang Z,Shan Y,Wu X,Liu H

Sat Feb 01 00:00:00 UTC 2020

The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats.

Frontiers in neuroscience

Yang F,Shan Y,Tang Z,Wu X,Bi C,Zhang Y,Gao Y,Liu H

Fri Apr 08 00:00:00 UTC 2022

Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.

Cells

Van Acker ZP,Van Raemdonck GA,Logie E,Van Acker SI,Baggerman G,Vanden Berghe W,Ponsaerts P,Dewilde S

Sun Aug 11 00:00:00 UTC 2019

Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na⁺/K⁺ ATPases.

Cell death & disease